Inhibiting the key gene involved in cancer drug resistance could dull the anti-cancer immune response by inhibiting a type of T lymphocytes, a study from Sundrud lab finds.
Dyclonine, an anesthetic found in some sore-throat products, protected cultured neurons against glutamate and peroxide toxicity.
"This compound can stop its messenger RNA from being recognized by a ribosome," professor Disney said. "We believe this unique mechanism is broadly applicable."
JUPITER, FLA – Scientists at UF Scripps Biomedical Research have developed a special molecular switch that could be embedded into gene therapies to allow doctors to control dosing. The feat, reported in the scientific journal Nature Biotechnology, offers gene therapy designers what may be the first viable…
Professor Courtney Miller, PhD, of the departments of Neuroscience and Molecular Medicine. JUPITER, FL — Fight or flight, panic, trembling: Our brains are wired to ensure we respond instantly to fear. While that fear response may save our lives in the dangerous moment, at times people stay on high…
JUPITER, FL — Our cells’ process for transforming genes into useful proteins works much like an automobile factory’s assembly line; there are schematics, parts, workers, motors, quality control systems and even recycling crews. If the cell’s recycling process falters, abnormal protein fragments accumulate, potentially causing the cell’s death. In nerve…
Altering the activity of the PPARg receptor could limit the side-effects of a useful group of diabetes drugs, TZDs.
The number of vesicles at specific types of synapses lead to better memory formation, Davis' team discovered.
Professor Courtney Miller is developing a compound designed to directly target neurons involved in methamphetamine cravings. Photo by Scott Wiseman. JUPITER, FL – New research raises the possibility that a wider group of people in recovery from substance use disorders may benefit from a relapse-prevention compound designed by UF Scripps…
The structure of the ROR1-binding arm of the bi-specific antibody in complex with ROR1 was determined by X-ray crystallography. Our immune system’s arsenal of defenses usually protects us from cancer. But sometimes, cancer cells overwhelm or evade this elaborate defense system. In a study in PNAS, Immunology…
