expanding knowledge Lab news from The Wertheim UF Scripps Institute

Where scientists push the boundaries of human knowledge to solve humanity’s most pressing health challenges. Read about our latest discoveries, awards and announcements below.

Structure of Factor Involved in Major Depression Solved

Historically, GPR158 hasn’t been easy to study. It is called an “orphan receptor” because scientists haven’t yet identified the molecule responsible for turning its signaling function “on” in a manner similar to flipping a switch. It may play a role in depression and anxiety.

The CryoEM structure of GPR158, involved in mood disorders, from Martemyanov lab.

Potential ALS, Dementia Drug Targets RNA

The successful compound works by binding tightly to the disease-causing RNA in multiple places, while also attracting an enzyme that eliminates RNAs.

Induced neurons derived from ALS patients helped scientists test their compounds.

Wiring the Eyes to the Brain for Color Vision

Martemyanov lab at UF Scripps solves the mystery of how cones form their distinctive brain connections, giving humans and other animals their ability to see colors. 

Mouse retinal neurons from Martemyanov lab at UF Scripps.

Discovery Offers New Arthritis Target

Reactivating chondrocytes, the cells that create cartilage, may offer a way to regenerate the joint cushions that degrade with age.

Griffin

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The Center for Inflammation Science and Systems Medicine

The Progressive Pulmonary Fibrosis Symposium 2026

On April 20, 2026, the Center for Inflammation Science and Systems Medicine at The Wertheim UF Scripps Institute will host a day-long symposium on progressive pulmonary fibrosis, a condition that causes a buildup of scar tissue in the lungs. See the speakers and details at the link.