Nettles

Kendall Nettles, Ph.D., applies detailed 3-D views and computer models to reveal how hormones, the body’s chemical messengers, and their receptors work. The goal? To tackle real‑world medical problems, including cancer drug resistance. Nettles’ lab works to translate molecular-level discoveries into better, safer medicines. Exploring the…

By distorting estrogen receptor shape in two different ways, compounds offer a two-for-one punch to estrogen-sensitive cancer cells. Kendall Nettles, PhD, (center) meets with two students in his lab, Jacqline Njeri (left) and Charles Min (right). Nettles and colleagues designed drug-like molecules that appear to fight estrogen-sensitive breast cancer in…