Enediynes can bind and break DNA, leading to cell death. As a result, they have enormous potential as antibiotics and cancer drugs. A new study reveals how nature assembles them.
Two scientists at UF Scripps have been recognized with "Invention of the Year" awards from UF Innovate. Read about their inventions.
A trailblazing scientist targets ALS, myotonic dystrophy, Parkinson’s, metastatic breast cancer, viral diseases and more by attacking key RNA, preventing disease-causing genes from being expressed in the first place.
The findings show it is possible to substantially accelerate the drug discovery process. The technique opens new doors to treating diseases by targeting their RNA processes, said Disney.
The Karbstein lab has discovered how ribosomes are remodeled in response to stress, altering their protein output.
expanding knowledge Lab news from The Wertheim UF Scripps Institute…
By distorting estrogen receptor shape in two different ways, compounds offer a two-for-one punch to estrogen-sensitive cancer cells. Kendall Nettles, PhD, (center) meets with two students in his lab, Jacqline Njeri (left) and Charles Min (right). Nettles and colleagues designed drug-like molecules that appear to fight estrogen-sensitive breast cancer in…
Scientists devise process for making precision anti-inflammatory medicines with fewer side-effects at UF Scripps Biomedical Research in Jupiter, Florida.
Inhibiting the key gene involved in cancer drug resistance could dull the anti-cancer immune response by inhibiting a type of T lymphocytes, a study from Sundrud lab finds.
The structure of the ROR1-binding arm of the bi-specific antibody in complex with ROR1 was determined by X-ray crystallography. Our immune system’s arsenal of defenses usually protects us from cancer. But sometimes, cancer cells overwhelm or evade this elaborate defense system. In a study in PNAS, Immunology…
