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expanding knowledge Lab news from The Wertheim UF Scripps Institute…

Dual-Action Breast Cancer Compounds Overcome Common Drug-Resistance Issues

Kendall Nettles, PhD, (center) meets with two students in his lab, Jacqline Njeri (left) and Charles Min (right). Nettles and colleagues designed drug-like molecules that appear to fight estrogen-sensitive breast cancer in two ways, in cell studies. Njeri and Min are co-authors on the paper, published August 27, 2021, in…

Toward Safer Steroids

Scientists devise process for making precision anti-inflammatory medicines with fewer side-effects at UF Scripps Biomedical Research in Jupiter, Florida.

Two-Pronged Antibodies Draw Immune Killers Directly to Cancer Cells

The structure of the ROR1-binding arm of the bi-specific antibody in complex with ROR1 was determined by X-ray crystallography. Our immune system’s arsenal of defenses usually protects us from cancer. But sometimes, cancer cells overwhelm or evade this elaborate defense system. In a study in PNAS, Immunology and Microbiology…