Kendall Nettles, Ph.D., employs computer models to reveal how hormones, the body’s chemical messengers, and their receptors work together. The goal? To tackle real-world medical problems, including cancer drug resistance. Kendall Nettles, Ph.D., uses structural biology to improve treatments of hormone dependent cancers. Exploring…
A team led by chemistry professor Ben Shen, Ph.D., discovered a potent anti-cancer compound within the institute's natural products collection. It has been connected to a precise cancer-seeking antibody with an innovative linker molecule.
The findings show it is possible to substantially accelerate the drug discovery process. The technique opens new doors to treating diseases by targeting their RNA processes, said Disney.
expanding knowledge Lab news from The Wertheim UF Scripps Institute…
By distorting estrogen receptor shape in two different ways, compounds offer a two-for-one punch to estrogen-sensitive cancer cells. Kendall Nettles, PhD, (center) meets with two students in his lab, Jacqline Njeri (left) and Charles Min (right). Nettles and colleagues designed drug-like molecules that appear to fight estrogen-sensitive breast cancer in…
The structure of the ROR1-binding arm of the bi-specific antibody in complex with ROR1 was determined by X-ray crystallography. Our immune system’s arsenal of defenses usually protects us from cancer. But sometimes, cancer cells overwhelm or evade this elaborate defense system. In a study in PNAS, Immunology…
