Donna Zhang

Donna Zhang,

Dr. Herbert A. Wertheim Professor

Department: SR-CISSM-ZHANG LAB
Business Phone: (561) 228-2560
Business Email: zhangd1@ufl.edu

About Donna Zhang

Dr. Donna D. Zhang, Ph.D., is a distinguished molecular toxicologist renowned for her groundbreaking research in understanding the mechanisms underlying various diseases and developing innovative therapeutic strategies. She earned her Ph.D. in Molecular Toxicology from New York University’s Nelson Institute of Environmental Medicine in 1997, focusing on the identification and characterization of the novel gene Cap43 induced by Ni2+ compounds. Throughout her illustrious career, she has held several esteemed academic positions, including her current role as the Dr. Herbert A. Wertheim Professor at the Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology at the University of Florida. Prior to this, Dr. Zhang served as the Musil Family Endowed Chair in Drug Discovery at the College of Pharmacy at the University of Arizona, where she made significant contributions to the field through her research and teaching.

With a passion for education and mentorship, Dr. Zhang has made significant contributions to the field through her teaching and supervision of Ph.D. students. She has developed and coordinated various courses in pharmacology and toxicology, shaping the next generation of scientists and pharmacists. Additionally, she actively engages in service and outreach activities both within her institution and externally, serving on numerous committees and review panels for prestigious organizations such as NIH and the Society of Toxicology. Dr. Zhang’s dedication to advancing scientific knowledge and her commitment to training future leaders in the field underscore her invaluable contributions to the scientific community.

Accomplishments

The 2024 Leading Edge in Basic Science Award at the 63rd Annual SOT meeting
2024 · SOT
The Distinguished Chinese American Toxicologist Award, AACT, Society of Toxicology
2023 · AACT, Society of Toxicology
Dr. James R. Halpert Faculty Research Award
2019 · University of Arizona
Centennial Top 100 Alumni Achievement Hall of Fame of Ningbo Xiaoshi High School, Ningbo, China. (Alumni: Tu Youyou, 2015 Nobel Prize in Physiology or Medicine)
2013 · Ningbo Xiaoshi High School
The Society of Toxicology Achievement Award
2012 · The Society of Toxicology

Research Profile

My research endeavors explore the intricate mechanisms of NRF2 redox biology, the pathogenesis of arsenic, and the development of preclinical drugs targeting NRF2. The goal is to leverage the body’s own defense systems, particularly the NRF2 pathway, to combat human diseases. NRF2, a pivotal transcription factor, orchestrates the cellular defense against environmental insults by regulating genes critical for maintaining redox and metabolic homeostasis.

Since NRF2’s discovery, it has been championed for its protective role against oxidative stress. Nonetheless, research from my laboratory has exposed its paradoxical role in cancer progression and therapy resistance. Our recent pioneering work has linked NRF2 high expression in certain cancers to enhanced survival and resistance to a new class of cell death, ferroptosis. These studies have significant implications, as NRF2 inhibition could transform therapeutic approaches for treatment-resistant cancers.

Additionally, my team’s research has implicated persistent NRF2 activation in the carcinogenic and diabetogenic effects of arsenic, a notorious environmental toxin affecting millions globally. This has set the stage for the development of specific NRF2 inhibitors, a yet unmet need in the field, to dissect NRF2’s detrimental roles in disease.

In summary, my lab’s efforts are directed towards: Unraveling the NRF2 signaling network. Deciphering NRF2 dysregulation in arsenic-induced carcinogenesis and diabetes. Developing NRF2-centric therapeutic strategies, including small molecules and nanobodies. Investigating the molecular biology of the CNC family proteins (NRF1, NRF2, and NRF3). The ultimate aim is to mitigate the impact of diseases exacerbated by environmental factors like arsenic, through innovative NRF2-targeted interventions.

Open Researcher and Contributor ID (ORCID)

0000-0002-8972-697X

Areas of Interest
  • Cancer
  • Diabetes
  • Ferroptosis
  • NRF2
  • NRF2-Keap-ARE pathway
  • arsenic toxicity
  • autophagy
  • redox biology

Publications

2024
A guideline on the molecular ecosystem regulating ferroptosis.
Nature cell biology. [DOI] 10.1038/s41556-024-01360-8. [PMID] 38424270.
2024
Erratum to “NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice”.
Aging and disease. 15(3):951-952 [DOI] 10.14336/AD.2023.10917. [PMID] 37728584.
2024
Human Hsp70 Substrate-Binding Domains Recognize Distinct Client Proteins.
Biochemistry. 63(3):251-263 [DOI] 10.1021/acs.biochem.3c00531. [PMID] 38243804.
2024
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.
Autophagy. 1-34 [DOI] 10.1080/15548627.2024.2319901. [PMID] 38442890.
2024
Ironing out the details of ferroptosis.
Nature cell biology. [DOI] 10.1038/s41556-024-01361-7. [PMID] 38429476.
2024
Natural inhibitor found for cell death by ferroptosis.
Nature. 626(7998):269-270 [DOI] 10.1038/d41586-024-00080-1. [PMID] 38297047.
2023
Anti-Ferroptotic Effects of Nrf2: Beyond the Antioxidant Response.
Molecules and cells. 46(3):165-175 [DOI] 10.14348/molcells.2023.0005. [PMID] 36994475.
2023
Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease.
Redox biology. 59 [DOI] 10.1016/j.redox.2022.102570. [PMID] 36495698.
2023
Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78.
Journal of medicinal chemistry. 66(1):677-694 [DOI] 10.1021/acs.jmedchem.2c01631. [PMID] 36516003.
2023
Involvement of eNAMPT/TLR4 inflammatory signaling in progression of non-alcoholic fatty liver disease, steatohepatitis, and fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 37(3) [DOI] 10.1096/fj.202201972RR. [PMID] 36809677.
2023
NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8.
Science advances. 9(5) [DOI] 10.1126/sciadv.ade9585. [PMID] 36724221.
2023
Physachenolide C is a Potent, Selective BET Inhibitor.
Journal of medicinal chemistry. 66(1):913-933 [DOI] 10.1021/acs.jmedchem.2c01770. [PMID] 36577036.
2023
Stapled Peptides as Direct Inhibitors of Nrf2-sMAF Transcription Factors.
Journal of medicinal chemistry. 66(9):6184-6192 [DOI] 10.1021/acs.jmedchem.2c02037. [PMID] 37097833.
2023
The dark side of NRF2 in arsenic carcinogenesis.
Advances in pharmacology (San Diego, Calif.). 96:47-69 [DOI] 10.1016/bs.apha.2022.08.002. [PMID] 36858779.
2023
The NRF2-p97-NRF2 negative feedback loop.
Redox biology. 65 [DOI] 10.1016/j.redox.2023.102839. [PMID] 37573837.
2023
The pyrimidinosome is cancer’s Achilles’ heel.
Nature cell biology. 25(6):798-799 [DOI] 10.1038/s41556-023-01159-z. [PMID] 37291266.
2022
Allosteric differences dictate GroEL complementation of E. coli.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36(3) [DOI] 10.1096/fj.202101708RR. [PMID] 35199390.
2022
CHML is an NRF2 target gene that regulates mTOR function.
Molecular oncology. 16(8):1714-1727 [DOI] 10.1002/1878-0261.13194. [PMID] 35184380.
2022
Differential Effects of Arsenic in Drinking Water on Mouse Hepatic and Intestinal Heme Oxygenase-1 Expression.
Antioxidants (Basel, Switzerland). 11(9) [DOI] 10.3390/antiox11091835. [PMID] 36139908.
2022
eNAMPT neutralization reduces preclinical ARDS severity via rectified NFkB and Akt/mTORC2 signaling.
Scientific reports. 12(1) [DOI] 10.1038/s41598-021-04444-9. [PMID] 35027578.
2022
Interactions between arsenic exposure, high-fat diet and NRF2 shape the complex responses in the murine gut microbiome and hepatic metabolism.
Frontiers in microbiomes. 1 [DOI] 10.3389/frmbi.2022.1041188. [PMID] 37779901.
2022
NRF2 and Diabetes: The Good, the Bad, and the Complex.
Diabetes. 71(12):2463-2476 [DOI] 10.2337/db22-0623. [PMID] 36409792.
2022
TLR4 activation induces inflammatory vascular permeability via Dock1 targeting and NOX4 upregulation.
Biochimica et biophysica acta. Molecular basis of disease. 1868(12) [DOI] 10.1016/j.bbadis.2022.166562. [PMID] 36179995.
2021
An NRF2 Perspective on Stem Cells and Ageing.
Frontiers in aging. 2 [DOI] 10.3389/fragi.2021.690686. [PMID] 36213179.
2021
Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action.
Journal of medicinal chemistry. 64(21):15727-15746 [DOI] 10.1021/acs.jmedchem.1c01014. [PMID] 34676755.
2021
FAM129B-dependent activation of NRF2 promotes an invasive phenotype in BRAF mutant melanoma cells.
Molecular carcinogenesis. 60(5):331-341 [DOI] 10.1002/mc.23295. [PMID] 33684228.
2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Autophagy. 17(1):1-382 [DOI] 10.1080/15548627.2020.1797280. [PMID] 33634751.
2021
HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease.
Molecular cell. 81(24):5052-5065.e6 [DOI] 10.1016/j.molcel.2021.10.028. [PMID] 34847358.
2021
MGST1, a new soldier of NRF2 in the battle against ferroptotic death.
Cell chemical biology. 28(6):741-742 [DOI] 10.1016/j.chembiol.2021.05.013. [PMID] 34143955.
2021
Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism.
Molecular metabolism. 51 [DOI] 10.1016/j.molmet.2021.101243. [PMID] 33933676.
2021
NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice.
Aging and disease. 12(4):964-982 [DOI] 10.14336/AD.2021.0511. [PMID] 34221542.
2021
Targeting NRF2 to treat cancer.
Seminars in cancer biology. 76:61-73 [DOI] 10.1016/j.semcancer.2021.06.003. [PMID] 34102289.
2021
The intricacies of NRF2 regulation in cancer.
Seminars in cancer biology. 76:110-119 [DOI] 10.1016/j.semcancer.2021.05.016. [PMID] 34020028.
2021
The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis.
Redox biology. 38 [DOI] 10.1016/j.redox.2020.101766. [PMID] 33126057.
2020
Activation of NRF2 by topical apocarotenoid treatment mitigates radiation-induced dermatitis.
Redox biology. 37 [DOI] 10.1016/j.redox.2020.101714. [PMID] 32927319.
2020
Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis.
Cell chemical biology. 27(4):436-447 [DOI] 10.1016/j.chembiol.2020.03.011. [PMID] 32275864.
2020
Chronic arsenic exposure enhances metastatic potential via NRF2-mediated upregulation of SOX9.
Toxicology and applied pharmacology. 402 [DOI] 10.1016/j.taap.2020.115138. [PMID] 32682831.
2020
Dengue Virus Targets Nrf2 for NS2B3-Mediated Degradation Leading to Enhanced Oxidative Stress and Viral Replication.
Journal of virology. 94(24) [DOI] 10.1128/JVI.01551-20. [PMID] 32999020.
2020
Filtering through the role of NRF2 in kidney disease.
Archives of pharmacal research. 43(3):361-369 [DOI] 10.1007/s12272-019-01177-2. [PMID] 31372933.
2020
NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.
PLoS biology. 18(2) [DOI] 10.1371/journal.pbio.3000620. [PMID] 32053600.
2020
The role of natural products in revealing NRF2 function.
Natural product reports. 37(6):797-826 [DOI] 10.1039/c9np00061e. [PMID] 32400766.
2020
Uremic toxins promote accumulation of oxidized protein and increased sensitivity to hydrogen peroxide in endothelial cells by impairing the autophagic flux.
Biochemical and biophysical research communications. 523(1):123-129 [DOI] 10.1016/j.bbrc.2019.12.022. [PMID] 31837804.
2019
A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78.
Bioorganic & medicinal chemistry letters. 29(14):1689-1693 [DOI] 10.1016/j.bmcl.2019.05.041. [PMID] 31129054.
2019
A one-step, atom economical synthesis of thieno[2,3-d]pyrimidin-4-amine derivatives via a four-component reaction.
European journal of organic chemistry. 20(2):3269-3272 [DOI] 10.1002/ejoc.201900414. [PMID] 31857792.
2019
An Isoform-Selective PTP1B Inhibitor Derived from Nitrogen-Atom Augmentation of Radicicol.
Biochemistry. 58(30):3225-3231 [DOI] 10.1021/acs.biochem.9b00499. [PMID] 31298844.
2019
Collective Cell Migration in 3D Epithelial Wound Healing.
ACS nano. 13(2):1204-1212 [DOI] 10.1021/acsnano.8b06305. [PMID] 30758172.
2019
Correction: Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2.
Cancer research. 79(5) [DOI] 10.1158/0008-5472.CAN-19-0070. [PMID] 30824678.
2019
Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells.
The Journal of biological chemistry. 294(48):18131-18149 [DOI] 10.1074/jbc.RA119.009591. [PMID] 31628195.
2019
Genome-Wide CRISPR Screen Reveals Autophagy Disruption as the Convergence Mechanism That Regulates the NRF2 Transcription Factor.
Molecular and cellular biology. 39(13) [DOI] 10.1128/MCB.00037-19. [PMID] 31010806.
2019
Modulating NRF2 in Disease: Timing Is Everything.
Annual review of pharmacology and toxicology. 59:555-575 [DOI] 10.1146/annurev-pharmtox-010818-021856. [PMID] 30256716.
2019
Non-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation.
Cell chemical biology. 26(10):1427-1435.e5 [DOI] 10.1016/j.chembiol.2019.07.011. [PMID] 31402317.
2019
NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis.
Redox biology. 23 [DOI] 10.1016/j.redox.2019.101107. [PMID] 30692038.
2019
One-Step Synthesis of Thieno[2,3-d]pyrimidin-4(3H)-ones via a Catalytic Four-Component Reaction of Ketones, Ethyl Cyanoacetate, S8 and Formamide.
ACS sustainable chemistry & engineering. 7(1):1524-1528 [DOI] 10.1021/acssuschemeng.8b05276. [PMID] 31754553.
2019
Redox regulation by NRF2 in aging and disease.
Free radical biology & medicine. 134:702-707 [DOI] 10.1016/j.freeradbiomed.2019.01.016. [PMID] 30654017.
2019
Spermidine Confers Liver Protection by Enhancing NRF2 Signaling Through a MAP1S-Mediated Noncanonical Mechanism.
Hepatology (Baltimore, Md.). 70(1):372-388 [DOI] 10.1002/hep.30616. [PMID] 30873635.
2018
A gapmer aptamer nanobiosensor for real-time monitoring of transcription and translation in single cells.
Biomaterials. 156:56-64 [DOI] 10.1016/j.biomaterials.2017.11.026. [PMID] 29190498.
2018
ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes.
Nature communications. 9(1) [DOI] 10.1038/s41467-018-06091-7. [PMID] 30201971.
2018
Increased O-GlcNAcylation of SNAP29 Drives Arsenic-Induced Autophagic Dysfunction.
Molecular and cellular biology. 38(11) [DOI] 10.1128/MCB.00595-17. [PMID] 29507186.
2018
Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2).
The Journal of biological chemistry. 293(6):2029-2040 [DOI] 10.1074/jbc.RA117.000428. [PMID] 29255090.
2018
Low-level arsenic causes proteotoxic stress and not oxidative stress.
Toxicology and applied pharmacology. 341:106-113 [DOI] 10.1016/j.taap.2018.01.014. [PMID] 29408041.
2018
NRF2 and the Hallmarks of Cancer.
Cancer cell. 34(1):21-43 [DOI] 10.1016/j.ccell.2018.03.022. [PMID] 29731393.
2018
NRF2 Induction for NASH Treatment: A New Hope Rises.
Cellular and molecular gastroenterology and hepatology. 5(3):422-423 [DOI] 10.1016/j.jcmgh.2017.12.009. [PMID] 29675456.
2018
RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression.
Proceedings of the National Academy of Sciences of the United States of America. 115(44):E10352-E10361 [DOI] 10.1073/pnas.1812125115. [PMID] 30309964.
2018
The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer.
Molecular carcinogenesis. 57(2):182-192 [DOI] 10.1002/mc.22745. [PMID] 28976703.
2018
The endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls a critical checkpoint in B cell development in mice.
The Journal of biological chemistry. 293(33):12934-12944 [DOI] 10.1074/jbc.RA117.001267. [PMID] 29907570.
2018
Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin.
Frontiers in pharmacology. 9 [DOI] 10.3389/fphar.2018.00287. [PMID] 29636694.
2017
ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells.
Molecular carcinogenesis. 56(6):1543-1553 [DOI] 10.1002/mc.22615. [PMID] 28112439.
2017
Arsenic Compromises Both p97 and Proteasome Functions.
Chemical research in toxicology. 30(7):1508-1514 [DOI] 10.1021/acs.chemrestox.7b00158. [PMID] 28636814.
2017
ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A.
Bioorganic & medicinal chemistry letters. 27(17):4082-4085 [DOI] 10.1016/j.bmcl.2017.07.045. [PMID] 28757063.
2017
Brusatol overcomes chemoresistance through inhibition of protein translation.
Molecular carcinogenesis. 56(5):1493-1500 [DOI] 10.1002/mc.22609. [PMID] 28019675.
2017
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.
Cell. 171(2):273-285 [DOI] 10.1016/j.cell.2017.09.021. [PMID] 28985560.
2017
Intercellular Tension Negatively Regulates Angiogenic Sprouting of Endothelial Tip Cells via Notch1-Dll4 Signaling.
Advanced biosystems. 1(1-2) [DOI] 10.1002/adbi.201600019. [PMID] 30662935.
2017
Multifunctional p62 Effects Underlie Diverse Metabolic Diseases.
Trends in endocrinology and metabolism: TEM. 28(11):818-830 [DOI] 10.1016/j.tem.2017.09.001. [PMID] 28966079.
2017
Non-canonical activation of NRF2: New insights and its relevance to disease.
Current pathobiology reports. 5(2):171-176 [DOI] 10.1007/s40139-017-0131-0. [PMID] 29082113.
2017
p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex.
Molecular and cellular biology. 37(8) [DOI] 10.1128/MCB.00660-16. [PMID] 28115426.
2017
Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin.
Nutrients. 9(12) [DOI] 10.3390/nu9121371. [PMID] 29258247.
2017
The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation.
Journal of immunology (Baltimore, Md. : 1950). 198(10):3927-3938 [DOI] 10.4049/jimmunol.1600312. [PMID] 28424240.
2016
An Essential Role of NRF2 in Diabetic Wound Healing.
Diabetes. 65(3):780-93 [DOI] 10.2337/db15-0564. [PMID] 26718502.
2016
Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30(7):2500-10 [DOI] 10.1096/fj.201500109R. [PMID] 27006451.
2016
Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner.
Scientific reports. 6 [DOI] 10.1038/srep18760. [PMID] 26729554.
2016
Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility.
PLoS computational biology. 12(5) [DOI] 10.1371/journal.pcbi.1004955. [PMID] 27196735.
2016
Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas.
Proceedings of the National Academy of Sciences of the United States of America. 113(37):10394-9 [DOI] 10.1073/pnas.1606742113. [PMID] 27573825.
2016
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy. 12(1):1-222 [DOI] 10.1080/15548627.2015.1100356. [PMID] 26799652.
2016
Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway.
Oncotarget. 7(9):10363-72 [DOI] 10.18632/oncotarget.7004. [PMID] 26824415.
2016
Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications.
Sensors (Basel, Switzerland). 16(4) [DOI] 10.3390/s16040476. [PMID] 27049392.
2016
NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis.
Science translational medicine. 8(334) [DOI] 10.1126/scitranslmed.aad6095. [PMID] 27075625.
2016
NRF2-targeted therapeutics: New targets and modes of NRF2 regulation.
Current opinion in toxicology. 1:62-70 [DOI] 10.1016/j.cotox.2016.10.005. [PMID] 29082352.
2016
Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle-age period.
Aging cell. 15(4):725-36 [DOI] 10.1111/acel.12482. [PMID] 27095375.
2016
Response to comment on “NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis”.
Science translational medicine. 8(349) [DOI] 10.1126/scitranslmed.aag1805. [PMID] 27464746.
2016
Role of Nrf2 and Autophagy in Acute Lung Injury.
Current pharmacology reports. 2(2):91-101 [PMID] 27313980.
2016
The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity.
Nature communications. 7 [DOI] 10.1038/ncomms12073. [PMID] 27417417.
2016
Ubiquitin-specific peptidase 22 functions and its involvement in disease.
Oncotarget. 7(28):44848-44856 [DOI] 10.18632/oncotarget.8602. [PMID] 27057639.
2015
A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Response.
Antioxidants & redox signaling. 23(8):651-64 [DOI] 10.1089/ars.2014.6074. [PMID] 25891177.
2015
Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene.
Drug metabolism and disposition: the biological fate of chemicals. 43(1):93-9 [DOI] 10.1124/dmd.114.060103. [PMID] 25349122.
2015
Induction of autophagy contributes to cisplatin resistance in human ovarian cancer cells.
Molecular medicine reports. 11(1):91-8 [DOI] 10.3892/mmr.2014.2671. [PMID] 25322694.
2015
Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention.
Biochemical Society transactions. 43(4):680-6 [DOI] 10.1042/BST20150020. [PMID] 26551712.
2015
Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration.
Nature communications. 6 [DOI] 10.1038/ncomms7556. [PMID] 25766473.
2015
Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde.
Cancer prevention research (Philadelphia, Pa.). 8(5):444-54 [DOI] 10.1158/1940-6207.CAPR-14-0359. [PMID] 25712056.
2015
Nuclear factor, erythroid 2-like 2-associated molecular signature predicts lung cancer survival.
Scientific reports. 5 [DOI] 10.1038/srep16889. [PMID] 26596768.
2015
Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy?
Molecular carcinogenesis. 54(11):1494-502 [DOI] 10.1002/mc.22202. [PMID] 25154499.
2015
p62 links autophagy and Nrf2 signaling.
Free radical biology & medicine. 88(Pt B):199-204 [DOI] 10.1016/j.freeradbiomed.2015.06.014. [PMID] 26117325.
2015
Single cell nanobiosensors for dynamic gene expression profiling in native tissue microenvironments.
Advanced materials (Deerfield Beach, Fla.). 27(39):6034-8 [DOI] 10.1002/adma.201502814. [PMID] 26314800.
2015
Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2.
Free radical biology & medicine. 89:690-700 [DOI] 10.1016/j.freeradbiomed.2015.08.028. [PMID] 26456052.
2015
The Histone Acetyltransferase GCN5 Expression Is Elevated and Regulated by c-Myc and E2F1 Transcription Factors in Human Colon Cancer.
Gene expression. 16(4):187-96 [DOI] 10.3727/105221615X14399878166230. [PMID] 26637399.
2015
Withaferin A Analogs That Target the AAA+ Chaperone p97.
ACS chemical biology. 10(8):1916-1924 [DOI] 10.1021/acschembio.5b00367. [PMID] 26006219.
2014
Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action.
Chembiochem : a European journal of chemical biology. 15(14):2125-31 [DOI] 10.1002/cbic.201402258. [PMID] 25125376.
2014
Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis.
Genes & development. 28(7):708-22 [DOI] 10.1101/gad.238246.114. [PMID] 24636985.
2014
Mapping photothermally induced gene expression in living cells and tissues by nanorod-locked nucleic acid complexes.
ACS nano. 8(4):3597-605 [DOI] 10.1021/nn500107g. [PMID] 24645754.
2014
Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma.
International journal of clinical and experimental pathology. 7(4):1502-13 [PMID] 24817946.
2014
Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response.
Kidney international. 85(2):333-343 [DOI] 10.1038/ki.2013.343. [PMID] 24025640.
2014
Oncogenic KRAS confers chemoresistance by upregulating NRF2.
Cancer research. 74(24):7430-41 [DOI] 10.1158/0008-5472.CAN-14-1439. [PMID] 25339352.
2014
Plant extracts of the family Lauraceae: a potential resource for chemopreventive agents that activate the nuclear factor-erythroid 2-related factor 2/antioxidant response element pathway.
Planta medica. 80(5):426-34 [DOI] 10.1055/s-0034-1368197. [PMID] 24585092.
2014
Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription.
Free radical biology & medicine. 67:69-80 [DOI] 10.1016/j.freeradbiomed.2013.10.806. [PMID] 24140708.
2014
Probing mechanoregulation of neuronal differentiation by plasma lithography patterned elastomeric substrates.
Scientific reports. 4 [DOI] 10.1038/srep06965. [PMID] 25376886.
2014
Single cell gene expression analysis in injury-induced collective cell migration.
Integrative biology : quantitative biosciences from nano to macro. 6(2):192-202 [DOI] 10.1039/c3ib40095f. [PMID] 24336811.
2013
Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner.
Molecular and cellular biology. 33(12):2436-46 [DOI] 10.1128/MCB.01748-12. [PMID] 23589329.
2013
Arsenic-mediated activation of the Nrf2-Keap1 antioxidant pathway.
Journal of biochemical and molecular toxicology. 27(2):99-105 [DOI] 10.1002/jbt.21463. [PMID] 23188707.
2013
Bardoxolone brings Nrf2-based therapies to light.
Antioxidants & redox signaling. 19(5):517-8 [DOI] 10.1089/ars.2012.5118. [PMID] 23227819.
2013
Detection of mRNA in living cells by double-stranded locked nucleic acid probes.
The Analyst. 138(17):4777-85 [DOI] 10.1039/c3an00722g. [PMID] 23772441.
2013
Nrf2 is crucial to graft survival in a rodent model of heart transplantation.
Oxidative medicine and cellular longevity. 2013 [DOI] 10.1155/2013/919313. [PMID] 23533698.
2013
Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy.
Experimental cell research. 319(17):2673-83 [DOI] 10.1016/j.yexcr.2013.07.015. [PMID] 23896025.
2013
Nrf2 pathway regulates multidrug-resistance-associated protein 1 in small cell lung cancer.
PloS one. 8(5) [DOI] 10.1371/journal.pone.0063404. [PMID] 23667609.
2013
Single cell antimicrobial susceptibility testing by confined microchannels and electrokinetic loading.
Analytical chemistry. 85(8):3971-6 [DOI] 10.1021/ac4004248. [PMID] 23445209.
2013
Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo.
Antioxidants & redox signaling. 19(14):1647-61 [DOI] 10.1089/ars.2012.5117. [PMID] 23394605.
2013
The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death.
Autophagy. 9(12):2087-102 [DOI] 10.4161/auto.26506. [PMID] 24113242.
2013
The emerging role of the Nrf2-Keap1 signaling pathway in cancer.
Genes & development. 27(20):2179-91 [DOI] 10.1101/gad.225680.113. [PMID] 24142871.
2013
The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV.
Redox biology. 1(1):532-41 [DOI] 10.1016/j.redox.2013.10.004. [PMID] 24273736.
2013
The predicted molecular weight of Nrf2: it is what it is not.
Antioxidants & redox signaling. 18(1):91-3 [DOI] 10.1089/ars.2012.4754. [PMID] 22703241.
2013
Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis.
The EMBO journal. 32(18):2477-90 [DOI] 10.1038/emboj.2013.183. [PMID] 23942232.
2013
Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival.
Cell cycle (Georgetown, Tex.). 12(14):2321-8 [DOI] 10.4161/cc.25404. [PMID] 24067374.
2013
USP15 negatively regulates Nrf2 through deubiquitination of Keap1.
Molecular cell. 51(1):68-79 [DOI] 10.1016/j.molcel.2013.04.022. [PMID] 23727018.
2012
Advances in wound-healing assays for probing collective cell migration.
Journal of laboratory automation. 17(1):59-65 [DOI] 10.1177/2211068211426550. [PMID] 22357609.
2012
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition.
PloS one. 7(7) [DOI] 10.1371/journal.pone.0041831. [PMID] 22848625.
2012
Does Nrf2 contribute to p53-mediated control of cell survival and death?
Antioxidants & redox signaling. 17(12):1670-5 [DOI] 10.1089/ars.2012.4674. [PMID] 22559194.
2012
Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 50(6):1927-32 [DOI] 10.1016/j.fct.2012.03.059. [PMID] 22465804.
2012
PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function.
Molecular and cellular biology. 32(8):1506-17 [DOI] 10.1128/MCB.06271-11. [PMID] 22331464.
2012
Regulation of transforming growth factor β1-dependent aldose reductase expression by the Nrf2 signal pathway in human mesangial cells.
European journal of cell biology. 91(10):774-81 [DOI] 10.1016/j.ejcb.2012.07.004. [PMID] 22951256.
2012
Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response.
Toxicology and applied pharmacology. 265(3):292-9 [DOI] 10.1016/j.taap.2012.08.028. [PMID] 22975029.
2012
USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development.
Molecular cell. 46(4):484-94 [DOI] 10.1016/j.molcel.2012.03.024. [PMID] 22542455.
2011
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism.
Proceedings of the National Academy of Sciences of the United States of America. 108(4):1433-8 [DOI] 10.1073/pnas.1014275108. [PMID] 21205897.
2011
KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response.
Molecular and cellular biology. 31(9):1800-11 [DOI] 10.1128/MCB.05036-11. [PMID] 21383067.
2011
The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation.
The Journal of biological chemistry. 286(19):16967-75 [DOI] 10.1074/jbc.M111.218206. [PMID] 21454709.
2011
Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy.
Diabetes. 60(11):3055-66 [DOI] 10.2337/db11-0807. [PMID] 22025779.
2010
A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
Molecular and cellular biology. 30(13):3275-85 [DOI] 10.1128/MCB.00248-10. [PMID] 20421418.
2010
A small-molecule inducer of the antioxidant response element.
Chemistry & biology. 17(5):537-47 [DOI] 10.1016/j.chembiol.2010.03.013. [PMID] 20534351.
2010
Antimicrobial susceptibility testing using high surface-to-volume ratio microchannels.
Analytical chemistry. 82(3):1012-9 [DOI] 10.1021/ac9022764. [PMID] 20055494.
2010
High levels of Nrf2 determine chemoresistance in type II endometrial cancer.
Cancer research. 70(13):5486-96 [DOI] 10.1158/0008-5472.CAN-10-0713. [PMID] 20530669.
2010
Nrf2 expression in endometrial serous carcinomas and its precancers.
International journal of clinical and experimental pathology. 4(1):85-96 [PMID] 21228930.
2010
Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.
Antioxidants & redox signaling. 13(11):1699-712 [DOI] 10.1089/ars.2010.3211. [PMID] 20486766.
2010
Statistical metamodeling for revealing synergistic antimicrobial interactions.
PloS one. 5(11) [DOI] 10.1371/journal.pone.0015472. [PMID] 21124958.
2010
The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells.
Molecules (Basel, Switzerland). 15(5):3338-55 [DOI] 10.3390/molecules15053338. [PMID] 20657484.
2010
The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer.
Antioxidants & redox signaling. 13(11):1623-6 [DOI] 10.1089/ars.2010.3301. [PMID] 20486759.
2010
The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy.
Diabetes. 59(4):850-60 [DOI] 10.2337/db09-1342. [PMID] 20103708.
2009
Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response.
Molecular and cellular biology. 29(10):2658-72 [DOI] 10.1128/MCB.01639-08. [PMID] 19273602.
2009
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response.
Molecular cell. 34(6):663-73 [DOI] 10.1016/j.molcel.2009.04.029. [PMID] 19560419.
2009
Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.
PloS one. 4(5) [DOI] 10.1371/journal.pone.0005492. [PMID] 19424503.
2009
Hybridization kinetics of double-stranded DNA probes for rapid molecular analysis.
The Analyst. 134(8):1675-81 [DOI] 10.1039/b906077d. [PMID] 20448937.
2009
Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels.
Cell cycle (Georgetown, Tex.). 8(20):3255-6 [PMID] 19806015.
2009
Nrf2 promotes neuronal cell differentiation.
Free radical biology & medicine. 47(6):867-79 [DOI] 10.1016/j.freeradbiomed.2009.06.029. [PMID] 19573594.
2009
Nrf2 protects against As(III)-induced damage in mouse liver and bladder.
Toxicology and applied pharmacology. 240(1):8-14 [DOI] 10.1016/j.taap.2009.06.010. [PMID] 19538980.
2009
Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response.
PloS one. 4(8) [DOI] 10.1371/journal.pone.0006588. [PMID] 19668370.
2009
The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination.
Molecular and cellular biology. 29(19):5348-56 [DOI] 10.1128/MCB.00407-09. [PMID] 19651900.
2008
A double-stranded molecular probe for homogeneous nucleic acid analysis.
The Analyst. 133(8):1013-9 [DOI] 10.1039/b804853c. [PMID] 18645642.
2008
Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction.
Toxicology and applied pharmacology. 230(3):383-9 [DOI] 10.1016/j.taap.2008.03.003. [PMID] 18417180.
2008
Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress.
Free radical biology & medicine. 45(4):385-95 [DOI] 10.1016/j.freeradbiomed.2008.04.023. [PMID] 18482591.
2008
Dual roles of Nrf2 in cancer.
Pharmacological research. 58(5-6):262-70 [DOI] 10.1016/j.phrs.2008.09.003. [PMID] 18838122.
2008
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2.
Carcinogenesis. 29(6):1235-43 [DOI] 10.1093/carcin/bgn095. [PMID] 18413364.
2008
Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response.
Environmental health perspectives. 116(9):1154-61 [DOI] 10.1289/ehp.11464. [PMID] 18795156.
2008
Separation-free detection of nuclear factor kappa B with double-stranded molecular probes.
The Analyst. 133(8):998-1000 [DOI] 10.1039/b809113g. [PMID] 18645638.
2008
Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis.
EMBO reports. 9(5):480-5 [DOI] 10.1038/embor.2008.37. [PMID] 18369366.
2007
Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.
Molecular and cellular biology. 27(18):6334-49 [PMID] 17636022.
2007
Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity.
Toxicology and applied pharmacology. 225(2):206-13 [PMID] 17765279.
2006
Mechanistic studies of the Nrf2-Keap1 signaling pathway.
Drug metabolism reviews. 38(4):769-89 [PMID] 17145701.
2005
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
The Journal of biological chemistry. 280(34):30091-9 [PMID] 15983046.
2004
Crystal structure of the Kelch domain of human Keap1.
The Journal of biological chemistry. 279(52):54750-8 [PMID] 15475350.
2004
Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1.
Acta crystallographica. Section D, Biological crystallography. 60(Pt 12 Pt 2):2346-8 [PMID] 15583386.
2004
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
Molecular and cellular biology. 24(24):10941-53 [PMID] 15572695.
2003
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress.
Molecular and cellular biology. 23(22):8137-51 [PMID] 14585973.
2003
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival.
Molecular and cellular biology. 23(20):7198-209 [PMID] 14517290.
2002
Time course of quartz and TiO(2) particle-induced pulmonary inflammation and neutrophil apoptotic responses in rats.
Experimental lung research. 28(8):641-70 [PMID] 12490038.

Grants

Apr 2024 ACTIVE
NRF Transcription Factors in Environmental Stress and Disease Intervention
Role: Principal Investigator
Funding: NATL INST OF HLTH NIEHS

Education

Ph.D. in Molecular Toxicology
1997 · New York University, Nelson Institute of Environmental Medicine, New York, New York.
M.S. in Molecular Toxicology
1993 · New York University, Nelson Institute of Environmental Medicine, New York, New York.

Contact Details

Phones:
Business:
(561) 228-2560
Emails:
Business:
zhangd1@ufl.edu
Addresses:
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130 SCRIPPS WAY # B258F
JUPITER FL 33458