Jason Yuan

Jason Yuan,

Professor Of Molecular Medicine

Department: SR-CISSM-YUAN LAB
Business Phone: (561) 228-2624
Business Email: jyuan2@ufl.edu

About Jason Yuan

Jason Yuan, M.D., Ph.D., is a distinguished Professor at the Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology and serves as the Assistant Vice President for Research at UF Health, the University of Florida-Scripps Research in Florida.

He embarked on his academic journey by earning his medical degree from Suzhou Medical College (Suzhou, China) in 1983. Subsequently, he obtained his doctoral degree in physiology from Peking Union Medical College (Beijing, China) in 1993. Dr. Yuan further enriched his expertise through postdoctoral training in the University of Maryland at Baltimore. Dr. Yuan’s early research focused on unraveling the intricate cellular and molecular mechanisms underlying hypoxic pulmonary vasoconstriction. His groundbreaking work encompassed the electrophysiology of ion channels and transporters in vascular smooth muscle and endothelial cells, as well as the regulation of excitation-contraction (EC) coupling across various cell types, including smooth muscle cells, neurons, and cardiomyocytes. His seminal contributions have significantly advanced our understanding of pulmonary vascular physiology and pathophysiology. Dr. Yuan’s current research is primarily focused on defining pathogenic mechanisms of pulmonary arterial hypertension (PAH) and developing novel therapeutic approaches for PAH and other subtypes of pulmonary hypertension.

Notably, Dr. Yuan’s research in pulmonary vascular disease has propelled the field forward, shedding light on the pathogenic roles of ion channels and membrane receptors. His pioneering insights have paved the way for innovative therapeutic approaches to combat these diseases. Since 1993, Dr. Yuan has been continuously funded by the National Institutes of Health (NIH), a testament to the significance and impact of his research endeavors.

In recognition of his exemplary contributions to science, Dr. Yuan has been honored as a Fellow of prestigious organizations such as the American Association for the Advancement of Science, the American Heart Association, the American Thoracic Society, and The American Physiological Society. Additionally, he has been recognized as a Guggenheim Fellow and is an elected Member of the American Society for Clinical Investigation and the Association of American Physicians.

Dr. Yuan’s leadership extends beyond his research pursuits, as evidenced by his active involvement in advisory committees and editorial boards. He has chaired influential bodies such as the Respiratory Integrative Biology and Translational Research study section of the NIH and the Pulmonary Circulation Assembly of the American Thoracic Society. Currently, he serves as the Editor-in-Chief of the journal Pulmonary Circulation and on the editorial board of the American Journal of Physiology Cell Physiology, Circulation Research, American Journal of Respiratory and Critical Care Medicine.

Furthermore, Dr. Yuan’s scholarly contributions are evident in his role as a leading editor of several seminal books in the field of pulmonary circulation. His comprehensive reference book, “Textbook of Pulmonary Vascular Disease,” stands as a cornerstone resource for researchers and clinicians alike. Additionally, he has edited or co-edited numerous other influential works, further cementing his status as a leading authority in his field.

In collaboration with esteemed colleagues, Dr. Yuan has co-authored “Ganong’s Review of Medical Physiology,” a widely acclaimed resource in medical education.

Through his relentless pursuit of scientific excellence and commitment to advancing our understanding of pulmonary vascular diseases, Dr. Jason Yuan has made indelible contributions to the field of biomedical research and continues to inspire future generations of scientists.

Additional Positions:
Assistant Vice President for Research, UF Health
2024 – Current · The University of Florida-Scripps Research Institute

Accomplishments

Professor Sheila Glennis Haworth Memorial Lecture
2021 · Pulmonary Vascular Research Institute
Recognition Award for Scientific Accomplishments
2020 · American Thoracic Society
Leadership Award, Pulmonary Circulation Assembly
2019 · American Thoracic Society
Robert M. Berne Distinguished Lectureship
2018 · The American Physiologically Society
Kenneth D. Bloch Memorial Lecture
2017 · American Heart Association
Elected Member
2013 · Association of American Physicians (AAP)
PVRI Achievement Award
2012 · Pulmonary Vascular Research Institute
Guggenheim Fellowship Award (Guggenheim Fellow)
2008 · John Simon Guggenheim Memorial Foundation
Elected Member
2007 · The American Society for Clinical Investigation (ASCI)
Fellow
2007 · American Association for the Advancement of Science (AAAS)
Established Investigator Award
1998 · American Heart Association
Cournand and Comroe Young Investigator Award (Winner)
1995 · American Heart Association
Giles F. Filley Memorial Award for Excellence in Respiratory Physiology and Medicine
1995 · The American Physiological Society (APS)
Parker B. Francis Fellowship
1994 · The Francis Families Foundation

Research Profile

Dr. Jason Yuan’s illustrious academic career has been marked by groundbreaking research and significant contributions to the field of pulmonary vascular disease. Beginning as a Research Assistant Professor of Medicine at the University of Maryland School of Medicine from 1993 to 1998, he established himself as a pioneer in translational research by initiating projects using lung tissues and cells from patients with idiopathic pulmonary arterial hypertension (IPAH). His work focused on unraveling the pathogenic mechanisms underlying this disease.

In recognition of his outstanding contributions, Dr. Yuan was awarded the prestigious Parker B. Francis Fellowship from the Francis Families Foundation in 1994 and the Giles F. Filley Memorial Award for Excellence in Respiratory Physiology and Medicine from the American Physiological Society in 1995. Additionally, he was honored as the recipient of the Cournand and Comroe Young Investigator Award by the American Heart Association in 1995, further solidifying his reputation as a promising young investigator in the field.

Dr. Yuan’s dedication to advancing therapeutic approaches for pulmonary vascular disease led to his receipt of an Established Investigator Award from the American Heart Association in 1998. His pioneering work in identifying novel therapeutic strategies earned him recognition as one of the leading researchers in the field of pulmonary vascular disease and right heart failure.

In 1999, Dr. Yuan joined the University of California, San Diego, where he continued to expand his research interests to include chronic thromboembolic pulmonary hypertension, the functional role of ion channels in stem cell biology, and pharmacogenetics associated with pulmonary arterial hypertension. During his tenure at UC San Diego, he held key leadership positions, serving as Vice Chair for Research in the Department of Medicine from 2007 to 2010 and Associate Director for Research Training in the Division of Pulmonary and Critical Care Medicine from 2003 to 2010.

Dr. Yuan’s commitment to advancing translational medicine led him to the University of Illinois at Chicago in July 2010, where he assumed the role of Program Director in the newly established Institute for Personalized Respiratory Medicine. Additionally, he served as Vice Chair for Scholarly Activities in the Department of Medicine and Director of the Program in Pulmonary Vascular Disease and Right Heart Dysfunction at the Center for Cardiovascular Research.

In May 2010, Dr. Yuan was appointed Associate Vice President for Translational Health Sciences at the University of Arizona, where he also became the founding Chief of the Division of Translational and Regenerative Medicine in the Department of Medicine. His leadership and expertise have significantly advanced the field of translational medicine, paving the way for innovative approaches to personalized healthcare.

Throughout his career, Dr. Yuan’s unwavering dedication to scientific inquiry and his pioneering research have earned him numerous accolades and recognition as a leading authority in pulmonary vascular disease and translational medicine. His groundbreaking work continues to impact the lives of patients and inspire future generations of researchers in the field.

Areas of Interest
  • acute pulmonary hypertension resulting from pulmonary embolism

Publications

2024
BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension.
Circulation. [DOI] 10.1161/CIRCULATIONAHA.123.066430. [PMID] 38557054.
2024
Ganong’s Physiology Examination & Board Review
Ganong’s Physiology Examination & Board Review . 2nd Edition
2024
Pulmonary primary oxysterol and bile acid synthesis as a predictor of outcomes in pulmonary arterial hypertension.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2024.01.20.576474. [PMID] 38328113.
2024
Rescuing lung development through embryonic inhibition of histone acetylation.
Science translational medicine. 16(732) [DOI] 10.1126/scitranslmed.adc8930. [PMID] 38295182.
2023
Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats.
British journal of pharmacology. 180(16):2102-2119 [DOI] 10.1111/bph.16064. [PMID] 36869838.
2023
Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity.
Chest. 163(1):204-215 [DOI] 10.1016/j.chest.2022.08.2230. [PMID] 36087794.
2023
Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling
Physiological Reviews. 103(3):1827-1897 [DOI] 10.1152/physrev.00030.2021. [PMID] 36422993.
2023
Pulmonary Arterial Hypertension
Fisherman's Pulmonary Diseases and Disorders. 1(6):1112-1256 [DOI] ISBN 978-1-260-47494-0.
2023
Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice.
Diabetes & vascular disease research. 20(3) [DOI] 10.1177/14791641231173630. [PMID] 37186669.
2023
Revisiting the Role of KCNA5 in Pulmonary Arterial Hypertension.
American journal of respiratory cell and molecular biology. 69(2):123-125 [DOI] 10.1165/rcmb.2023-0119ED. [PMID] 37201951.
2023
SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells.
Signal transduction and targeted therapy. 8(1) [DOI] 10.1038/s41392-023-01556-8. [PMID] 37452066.
2023
The Novel Lysosomal Autophagy Inhibitor (ROC-325) Ameliorates Experimental Pulmonary Hypertension.
Hypertension (Dallas, Tex. : 1979). 80(1):70-83 [DOI] 10.1161/HYPERTENSIONAHA.122.19397. [PMID] 36345832.
2023
Treatment of Pulmonary Arterial Hypertension
Goodman & Gilman’s The Pharmacological Basis of Therapeutics. (14):695-707 [DOI] ISBN 9781264258079.
2022
Author Correction: Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood.
Nature communications. 13(1) [DOI] 10.1038/s41467-022-33381-y. [PMID] 36433938.
2022
Clinical Characteristics and Transplant-Free Survival Across the Spectrum of Pulmonary Vascular Disease.
Journal of the American College of Cardiology. 80(7):697-718 [DOI] 10.1016/j.jacc.2022.05.038. [PMID] 35953136.
2022
Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype.
Sleep. 45(6) [DOI] 10.1093/sleep/zsab290. [PMID] 34893914.
2022
Cytokine profiling in pulmonary arterial hypertension: the role of redox homeostasis and sex.
Translational research : the journal of laboratory and clinical medicine. 247:1-18 [DOI] 10.1016/j.trsl.2022.03.013. [PMID] 35405322.
2022
Editorial: Calcium and pulmonary hypertension.
Frontiers in physiology. 13 [DOI] 10.3389/fphys.2022.1019158. [PMID] 36407003.
2022
Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial.
The Lancet. Respiratory medicine. 10(3):267-277 [DOI] 10.1016/S2213-2600(21)00454-9. [PMID] 34942085.
2022
Established pulmonary hypertension in rats was reversed by a combination of a HIF-2α antagonist and a p53 agonist.
British journal of pharmacology. 179(5):1065-1081 [DOI] 10.1111/bph.15696. [PMID] 34599843.
2022
Excess neuropeptides in lung signal through endothelial cells to impair gas exchange.
Developmental cell. 57(7):839-853.e6 [DOI] 10.1016/j.devcel.2022.02.023. [PMID] 35303432.
2022
Flavored and Nicotine-Containing E-Cigarettes Induce Impaired Angiogenesis and Diabetic Wound Healing via Increased Endothelial Oxidative Stress and Reduced NO Bioavailability.
Antioxidants (Basel, Switzerland). 11(5) [DOI] 10.3390/antiox11050904. [PMID] 35624768.
2022
Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia.
Human molecular genetics. 31(7):1130-1140 [DOI] 10.1093/hmg/ddab291. [PMID] 34718575.
2022
In Vivo and Ex Vivo Experimental Approach for Studying Functional Role of Notch in Pulmonary Vascular Disease.
Methods in molecular biology (Clifton, N.J.). 2472:209-220 [DOI] 10.1007/978-1-0716-2201-8_17. [PMID] 35674903.
2022
JAGGED-NOTCH3 signaling in vascular remodeling in pulmonary arterial hypertension.
Science translational medicine. 14(643) [DOI] 10.1126/scitranslmed.abl5471. [PMID] 35507674.
2022
Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells.
American journal of physiology. Cell physiology. 323(4):C959-C973 [DOI] 10.1152/ajpcell.00313.2022. [PMID] 35968892.
2022
Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation.
American journal of physiology. Lung cellular and molecular physiology. 322(5):L737-L760 [DOI] 10.1152/ajplung.00447.2021. [PMID] 35318857.
2022
MED1 Regulates BMP/TGF-β in Endothelium: Implication for Pulmonary Hypertension.
Circulation research. 131(10):828-841 [DOI] 10.1161/CIRCRESAHA.122.321532. [PMID] 36252121.
2022
Microbiome and metabolome dysbiosis of the gut-lung axis in pulmonary hypertension.
Microbiological research. 265 [DOI] 10.1016/j.micres.2022.127205. [PMID] 36202007.
2022
NEDD9 provides mechanistic insight into the coagulopathy of COVID-19.
Pulmonary circulation. 12(2) [DOI] 10.1002/pul2.12087. [PMID] 35599982.
2022
Pathogenic Mechanisms of Pulmonary Arterial Hypertension: Homeostasis Imbalance of Endothelium-Derived Relaxing and Contracting Factors.
JACC. Asia. 2(7):787-802 [DOI] 10.1016/j.jacasi.2022.09.010. [PMID] 36713766.
2022
Targeting ATP-Sensitive K+ Channels to Treat Pulmonary Hypertension.
American journal of respiratory cell and molecular biology. 66(5):476-478 [DOI] 10.1165/rcmb.2021-0549ED. [PMID] 35238728.
2022
Time Domains of Hypoxia Responses and -Omics Insights.
Frontiers in physiology. 13 [DOI] 10.3389/fphys.2022.885295. [PMID] 36035495.
2022
Upregulation of mechanosensitive channel Piezo1 involved in high shear stress-induced pulmonary hypertension.
Thrombosis research. 218:52-63 [DOI] 10.1016/j.thromres.2022.08.006. [PMID] 35988445.
2021
Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics.
Redox biology. 38 [DOI] 10.1016/j.redox.2020.101785. [PMID] 33221570.
2021
Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood.
Nature communications. 12(1) [DOI] 10.1038/s41467-021-27326-0. [PMID] 34876579.
2021
Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Hypertension
B5. B005 HERE COMES THE SUN – BASIC AND TRANSLATIONAL ADVANCES IN PULMONARY HYPERTENSION: LESSONS FROM BEST ABSTRACTS. [DOI] 10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1070.
2021
Design and Comprehensive Characterization of Tetramethylpyrazine (TMP) for Targeted Lung Delivery as Inhalation Aerosols in Pulmonary Hypertension (PH): In Vitro Human Lung Cell Culture and In Vivo Efficacy.
Antioxidants (Basel, Switzerland). 10(3) [DOI] 10.3390/antiox10030427. [PMID] 33799587.
2021
Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb.
Pulmonary circulation. 11(4) [DOI] 10.1177/20458940211059712. [PMID] 34790349.
2021
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension.
American journal of physiology. Cell physiology. 321(6):C1010-C1027 [DOI] 10.1152/ajpcell.00147.2021. [PMID] 34669509.
2021
Halofuginone, a promising drug for treatment of pulmonary hypertension.
British journal of pharmacology. 178(17):3373-3394 [DOI] 10.1111/bph.15442. [PMID] 33694155.
2021
HuR/Cx40 downregulation causes coronary microvascular dysfunction in type 2 diabetes.
JCI insight. 6(21) [DOI] 10.1172/jci.insight.147982. [PMID] 34747371.
2021
Hypoxia-induced pulmonary hypertension-Utilizing experiments of nature.
British journal of pharmacology. 178(1):121-131 [DOI] 10.1111/bph.15144. [PMID] 32464698.
2021
IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias.
Blood. 137(9):1208-1218 [DOI] 10.1182/blood.2020005944. [PMID] 33181835.
2021
Mouse model of experimental pulmonary hypertension: Lung angiogram and right heart catheterization.
Pulmonary circulation. 11(4) [DOI] 10.1177/20458940211041512. [PMID] 34531976.
2021
mTOR Signaling in Pulmonary Vascular Disease: Pathogenic Role and Therapeutic Target
International Journal of Molecular Sciences. 22(4) [DOI] 10.3390/ijms22042144. [PMID] 33670032.
2021
NEDD9, a Hypoxia-upregulated Mediator for Pathogenic Platelet-Endothelial Cell Interaction in Pulmonary Hypertension.
American journal of respiratory and critical care medicine. 203(12):1455-1458 [DOI] 10.1164/rccm.202101-0007ED. [PMID] 33770456.
2021
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2.
Circulation research. 128(9):1323-1326 [DOI] 10.1161/CIRCRESAHA.121.318902. [PMID] 33784827.
2021
TRPC6, a therapeutic target for pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology. 321(6):L1161-L1182 [DOI] 10.1152/ajplung.00159.2021. [PMID] 34704831.
2021
Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells.
Frontiers in physiology. 12 [DOI] 10.3389/fphys.2021.714785. [PMID] 34408668.
2021
Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients.
Hypertension (Dallas, Tex. : 1979). 77(6):1974-1989 [DOI] 10.1161/HYPERTENSIONAHA.120.16629. [PMID] 33813851.
2020
Advanced spray dried proliposomes of amphotericin B lung surfactant-mimic phospholipid microparticles/nanoparticles as dry powder inhalers for targeted pulmonary drug delivery.
Pulmonary pharmacology & therapeutics. 64 [DOI] 10.1016/j.pupt.2020.101975. [PMID] 33137515.
2020
Altered Airway Microbiota Composition in Patients With Pulmonary Hypertension.
Hypertension (Dallas, Tex. : 1979). 76(5):1589-1599 [DOI] 10.1161/HYPERTENSIONAHA.120.15025. [PMID] 32921193.
2020
Blue-/Green-Light-Responsive Cyanobacteriochromes Are Cell Shade Sensors in Red-Light Replete Niches.
iScience. 23(3) [DOI] 10.1016/j.isci.2020.100936. [PMID] 32146329.
2020
Chloroquine differentially modulates coronary vasodilation in control and diabetic mice.
British journal of pharmacology. 177(2):314-327 [DOI] 10.1111/bph.14864. [PMID] 31503328.
2020
Chronic Hypoxia Decreases Endothelial Connexin 40, Attenuates Endothelium-Dependent Hyperpolarization-Mediated Relaxation in Small Distal Pulmonary Arteries, and Leads to Pulmonary Hypertension.
Journal of the American Heart Association. 9(24) [DOI] 10.1161/JAHA.120.018327. [PMID] 33307937.
2020
Clinical implications of idiopathic pulmonary arterial hypertension phenotypes defined by cluster analysis.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 39(4):310-320 [DOI] 10.1016/j.healun.2019.12.012. [PMID] 32061507.
2020
Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α
American Journal of Respiratory Cell and Molecular Biology. 63(1):92-103 [DOI] 10.1165/rcmb.2019-0164oc. [PMID] 32142369.
2020
Endothelial platelet-derived growth factor-mediated activation of smooth muscle platelet-derived growth factor receptors in pulmonary arterial hypertension.
Pulmonary circulation. 10(3) [DOI] 10.1177/2045894020948470. [PMID] 33294172.
2020
Genetic Admixture and Survival in Diverse Populations with Pulmonary Arterial Hypertension.
American journal of respiratory and critical care medicine. 201(11):1407-1415 [DOI] 10.1164/rccm.201907-1447OC. [PMID] 31916850.
2020
MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension.
Circulation. 142(12):1190-1204 [DOI] 10.1161/CIRCULATIONAHA.120.048191. [PMID] 32755395.
2020
Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 26(10):1166-1172 [DOI] 10.4158/EP-2020-0466. [PMID] 33471718.
2020
MicroRNA-mediated downregulation of K+ channels in pulmonary arterial hypertension.
American journal of physiology. Lung cellular and molecular physiology. 318(1):L10-L26 [DOI] 10.1152/ajplung.00010.2019. [PMID] 31553627.
2020
mTORC1 in Pulmonary Arterial Hypertension. At the Crossroads between Vasoconstriction and Vascular Remodeling?
American journal of respiratory and critical care medicine. 201(10):1177-1179 [DOI] 10.1164/rccm.202001-0087ED. [PMID] 31968178.
2020
Notch enhances Ca2+ entry by activating calcium-sensing receptors and inhibiting voltage-gated K+ channels.
American journal of physiology. Cell physiology. 318(5):C954-C968 [DOI] 10.1152/ajpcell.00487.2019. [PMID] 32186932.
2020
Overexpression of p53 due to excess protein O-GlcNAcylation is associated with coronary microvascular disease in type 2 diabetes.
Cardiovascular research. 116(6):1186-1198 [DOI] 10.1093/cvr/cvz216. [PMID] 31504245.
2020
Revisiting the mechanism of hypoxic pulmonary vasoconstriction using isolated perfused/ventilated mouse lung.
Pulmonary circulation. 10(4) [DOI] 10.1177/2045894020956592. [PMID] 33282184.
2020
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2020.12.04.409144. [PMID] 33300001.
2020
Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension.
British journal of pharmacology. 177(12):2743-2764 [DOI] 10.1111/bph.15000. [PMID] 31976548.
2020
Transcriptomic profiles in pulmonary arterial hypertension associate with disease severity and identify novel candidate genes.
Pulmonary circulation. 10(4) [DOI] 10.1177/2045894020968531. [PMID] 33343881.
2020
Transplantation of Mesenchymal Stem Cells Attenuates Pulmonary Hypertension by Normalizing the Endothelial-to-Mesenchymal Transition.
American journal of respiratory cell and molecular biology. 62(1):49-60 [DOI] 10.1165/rcmb.2018-0165OC. [PMID] 31211918.
2019
A call to think about health rather than medicine
BMJ. [DOI] 10.1136/bmj.l256.
2019
Biomechanical Forces and Oxidative Stress: Implications for Pulmonary Vascular Disease.
Antioxidants & redox signaling. 31(12):819-842 [DOI] 10.1089/ars.2018.7720. [PMID] 30623676.
2019
Divergent changes of p53 in pulmonary arterial endothelial and smooth muscle cells involved in the development of pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology. 316(1):L216-L228 [DOI] 10.1152/ajplung.00538.2017. [PMID] 30358436.
2019
Endothelial Notch1 in Pulmonary Hypertension.
Circulation research. 124(2):176-179 [DOI] 10.1161/CIRCRESAHA.118.314496. [PMID] 30653427.
2019
EXPRESS: Surfing the Right Ventricular Pressure Waveform: Methods to assess Global, Systolic and Diastolic RV Function from a Clinical Right Heart Catheterization.
Pulmonary circulation. 10(1) [DOI] 10.1177/2045894019850993. [PMID] 31032737.
2019
Ganong’s Physiology Examination & Board Review
Ganong’s Review of Medical Physiology. 26th Edition [DOI] ISBN: 978-1-260-566666-6; MHID: 1-260-56666-8.
2019
Gender Difference in Damage-Mediated Signaling Contributes to Pulmonary Arterial Hypertension.
Antioxidants & redox signaling. 31(13):917-932 [DOI] 10.1089/ars.2018.7664. [PMID] 30652485.
2019
KCNK3 Channel: A New Player in the Field of Pulmonary Vascular Disease.
Circulation research. 125(7):696-698 [DOI] 10.1161/CIRCRESAHA.119.315758. [PMID] 31513487.
2019
Pathophysiology of stroke: what do cells of the neurovascular unit have to do with it?
American journal of physiology. Cell physiology. 316(1) [DOI] 10.1152/ajpcell.00470.2018. [PMID] 30462541.
2019
PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension.
Proceedings of the National Academy of Sciences of the United States of America. 116(27):13394-13403 [DOI] 10.1073/pnas.1821401116. [PMID] 31213542.
2018
AJP-Cell Physiology begins landmark reviews in cell physiology: an editorial from the senior editors of AJP-Cell Physiology.
American journal of physiology. Cell physiology. 314(1):C1-C2 [DOI] 10.1152/ajpcell.00256.2017. [PMID] 29092820.
2018
Bone Marrow-Derived Endothelial Progenitor Cells Contribute to Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibition of Store-Operated Ca2+ Channels.
BioMed research international. 2018 [DOI] 10.1155/2018/4892349. [PMID] 30320134.
2018
Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series)
Pulmonary Circulation. 8(1):1-17 [DOI] 10.1177/2045893217752912. [PMID] 29283043.
2018
Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition.
American journal of physiology. Lung cellular and molecular physiology. 314(2):L256-L275 [DOI] 10.1152/ajplung.00096.2017. [PMID] 29074488.
2018
Hypoxia selectively upregulates cation channels and increases cytosolic [Ca2+] in pulmonary, but not coronary, arterial smooth muscle cells.
American journal of physiology. Cell physiology. 314(4):C504-C517 [DOI] 10.1152/ajpcell.00272.2017. [PMID] 29351410.
2018
LPS-induced Acute Lung Injury Involves NF-κB-mediated Downregulation of SOX18.
American journal of respiratory cell and molecular biology. 58(5):614-624 [DOI] 10.1165/rcmb.2016-0390OC. [PMID] 29115856.
2018
New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension.
PloS one. 13(8) [DOI] 10.1371/journal.pone.0203493. [PMID] 30161219.
2018
Pathogenic role of mTORC1 and mTORC2 in pulmonary hypertension
JACC. Basic Trans. Sci. (3(6)):744-762
2018
Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension.
JACC. Basic to translational science. 3(6):744-762 [DOI] 10.1016/j.jacbts.2018.08.009. [PMID] 30623134.
2018
Pathophysiology of stroke: the many and varied contributions of brain microvasculature.
American journal of physiology. Cell physiology. 315(3):C341-C342 [DOI] 10.1152/ajpcell.00328.2018. [PMID] 30110563.
2018
Smooth muscle cell-specific FoxM1 controls hypoxia-induced pulmonary hypertension.
Cellular signalling. 51:119-129 [DOI] 10.1016/j.cellsig.2018.08.003. [PMID] 30092353.
2018
STIM2 (Stromal Interaction Molecule 2)-Mediated Increase in Resting Cytosolic Free Ca2+ Concentration Stimulates PASMC Proliferation in Pulmonary Arterial Hypertension.
Hypertension (Dallas, Tex. : 1979). 71(3):518-529 [DOI] 10.1161/HYPERTENSIONAHA.117.10503. [PMID] 29358461.
2018
STIM2-mediated increase in resting [Ca2+]cyt stimulates PASMC proliferation in pulmonary arterial hypertension.
Hypertention. 71: 518-529
2018
Structure-Function Analysis of the Bifunctional CcsBA Heme Exporter and Cytochrome c Synthetase.
mBio. 9(6) [DOI] 10.1128/mBio.02134-18. [PMID] 30563894.
2017
Capsaicin-induced Ca2+ signaling is enhanced via overexpressed TRPV1 channels in pulmonary arterial smooth muscle cells from patients with idiopathic pulmonary arterial hypertension
Am. J. Physiol. Lung Cell. Mol. Physiol. 312: L309-L325
2017
Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH.
American journal of physiology. Lung cellular and molecular physiology. 312(3):L309-L325 [DOI] 10.1152/ajplung.00357.2016. [PMID] 27979859.
2017
Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension.
British journal of pharmacology. 174(22):4155-4172 [DOI] 10.1111/bph.13990. [PMID] 28849593.
2017
Endothelial cell signaling and ventilator-induced lung injury: molecular mechanisms, genomic analyses, and therapeutic targets.
American journal of physiology. Lung cellular and molecular physiology. 312(4):L452-L476 [DOI] 10.1152/ajplung.00231.2016. [PMID] 27979857.
2017
How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension
European Respiratory Journal. 50(2) [DOI] 10.1183/13993003.00764-2017. [PMID] 28838981.
2017
Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury.
Free radical biology & medicine. 102:217-228 [DOI] 10.1016/j.freeradbiomed.2016.11.008. [PMID] 27838434.
2017
Is p38 MAPK a Dark Force in Right Ventricular Hypertrophy and Failure in Pulmonary Arterial Hypertension?
American journal of respiratory cell and molecular biology. 57(5):506-508 [DOI] 10.1165/rcmb.2017-0197ED. [PMID] 29090954.
2017
Nicotinamide phosphoribosyltransferase promotes pulmonary vascular remodeling and is a therapeutic target in pulmonary arterial hypertension
Circulation. 135(16):1532-1546 [DOI] 10.1161/CIRCULATIONAHA.116.024557. [PMID] 28202489.
2017
PVDOMICS
Circulation Research. 121(10):1136-1139 [DOI] 10.1161/circresaha.117.311737. [PMID] 29074534.
2017
Targeting L-arginine-nitric oxide-cGMP pathway in pulmonary arterial hypertension.
Pulmonary circulation. 7(3):569-571 [DOI] 10.1177/2045893217728261. [PMID] 28895506.
2017
The Pulmonary Vascular Research Institute celebrates its first decade.
Pulmonary circulation. 7(2):283-284 [DOI] 10.1177/2045893217713107. [PMID] 28597776.
2016
Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells.
American journal of respiratory cell and molecular biology. 55(2):275-87 [DOI] 10.1165/rcmb.2015-0185OC. [PMID] 26959555.
2016
ATP promotes cell survival via regulation of cytosolic [Ca2+] and Bcl-2/Bax ratio in lung cancer cells.
American journal of physiology. Cell physiology. 310(2):C99-114 [DOI] 10.1152/ajpcell.00092.2015. [PMID] 26491047.
2016
Calcium-Sensing Receptor Regulates Cytosolic [Ca 2+ ] and Plays a Major Role in the Development of Pulmonary Hypertension.
Frontiers in physiology. 7 [PMID] 27867361.
2016
Gasping for answers. Focus on “Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia”.
American journal of physiology. Cell physiology. 310(6):C432-3 [DOI] 10.1152/ajpcell.00017.2016. [PMID] 26843530.
2016
Genetic Insights into Pulmonary Arterial Hypertension. Application of Whole-Exome Sequencing to the Study of Pathogenic Mechanisms.
American journal of respiratory and critical care medicine. 194(4):393-7 [DOI] 10.1164/rccm.201603-0577ED. [PMID] 27525458.
2016
Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed Rat Lung.
PloS one. 11(3) [DOI] 10.1371/journal.pone.0150480. [PMID] 26937637.
2016
miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation.
Journal of the American Heart Association. 5(12) [PMID] 27919930.
2016
Our readership grows by leaps and bounds.
Pulmonary circulation. 6(4):405-406 [DOI] 10.1086/688929. [PMID] 28090284.
2016
Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension
American Journal of Physiology-Lung Cellular and Molecular Physiology. 310(9):L846-L859 [DOI] 10.1152/ajplung.00050.2016. [PMID] 26968768.
2016
Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation.
American journal of physiology. Heart and circulatory physiology. 311(4):H944-H957 [DOI] 10.1152/ajpheart.00040.2016. [PMID] 27591215.
2016
Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension.
Free radical biology & medicine. 95:96-111 [DOI] 10.1016/j.freeradbiomed.2016.02.029. [PMID] 26928584.
2016
Ryanodine receptor-2: a necessity for gating store-operated Ca2+ channels.
Cardiovascular research. 111(1):13-5 [DOI] 10.1093/cvr/cvw108. [PMID] 27229459.
2016
Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis.
American journal of physiology. Cell physiology. 311(1):C136-49 [DOI] 10.1152/ajpcell.00252.2015. [PMID] 27194472.
2016
Transcription factors, transcriptional coregulators, and epigenetic modulation in the control of pulmonary vascular cell phenotype: therapeutic implications for pulmonary hypertension (2015 Grover Conference series).
Pulmonary circulation. 6(4):448-464 [DOI] 10.1086/688908. [PMID] 28090287.
2015
Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells.
Redox biology. 6:278-286 [DOI] 10.1016/j.redox.2015.07.016. [PMID] 26298201.
2015
Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension
American Journal of Physiology-Lung Cellular and Molecular Physiology. 308(2):L208-L220 [DOI] 10.1152/ajplung.00242.2014. [PMID] 25416384.
2015
Loss of microRNA-17∼92 in smooth muscle cells attenuates experimental pulmonary hypertension via induction of PDZ and LIM domain 5.
American journal of respiratory and critical care medicine. 191(6):678-92 [DOI] 10.1164/rccm.201405-0941OC. [PMID] 25647182.
2015
Lung Stem Cells in the Epithelium and Vasculature
. [DOI] ISBN: 978-3-319-16231-7 (Print) 978-3-319-16232-4 .
2015
MicroRNAs and PARP: co-conspirators with ROS in pulmonary hypertension. Focus on “miR-223 reverses experimental pulmonary arterial hypertension”.
American journal of physiology. Cell physiology. 309(6):C361-2 [DOI] 10.1152/ajpcell.00209.2015. [PMID] 26201953.
2015
miRNA208/Mef2 and TNF-α in right ventricular dysfunction: the transition from hypertrophy to failure.
Circulation research. 116(1):6-8 [DOI] 10.1161/CIRCRESAHA.114.305446. [PMID] 25552686.
2015
New insights into the pathology of pulmonary hypertension: implication of the miR-210/ISCU1/2/Fe-S axis.
EMBO molecular medicine. 7(6):689-91 [DOI] 10.15252/emmm.201505160. [PMID] 25851536.
2015
Notch Activation of Ca2+ Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension
American Journal of Respiratory Cell and Molecular Biology. 53(3):355-367 [DOI] 10.1165/rcmb.2014-0235oc. [PMID] 25569851.
2015
Response to Letter Regarding Article, “The ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease”.
Circulation. 132(2) [DOI] 10.1161/CIRCULATIONAHA.114.014783. [PMID] 26169652.
2015
SGLT inhibitors attenuate NO-dependent vascular relaxation in the pulmonary artery but not in the coronary artery.
American journal of physiology. Lung cellular and molecular physiology. 309(9):L1027-36 [DOI] 10.1152/ajplung.00167.2015. [PMID] 26361875.
2015
The rise and rise of Pulmonary Circulation.
Pulmonary circulation. 5(1):1-2 [DOI] 10.1086/680857. [PMID] 25992266.
2015
Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype
American Journal of Physiology-Cell Physiology. 308(8):C581-C593 [DOI] 10.1152/ajpcell.00202.2014. [PMID] 25673771.
2014
[Effects of gender on severity and pulmonary artery vascular reactivity in chronic hypoxic pulmonary hypertension in mice].
Zhonghua yi xue za zhi. 94(22):1692-5 [PMID] 25151896.
2014
Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca2+entry in human pulmonary arterial smooth muscle cells
American Journal of Physiology-Cell Physiology. 306(9):C871-C878 [DOI] 10.1152/ajpcell.00221.2013. [PMID] 24573085.
2014
Breaking barriers in obstructive sleep apnea. Focus on “Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation”.
American journal of physiology. Cell physiology. 306(8):C724-5 [DOI] 10.1152/ajpcell.00072.2014. [PMID] 24627556.
2014
Deacetylation of MicroRNA-124 in fibroblasts: role in pulmonary hypertension.
Circulation research. 114(1):5-8 [DOI] 10.1161/CIRCRESAHA.113.302838. [PMID] 24385500.
2014
Differentially expressed plasma microRNAs and the potential regulatory function of Let-7b in chronic thromboembolic pulmonary hypertension.
PloS one. 9(6) [DOI] 10.1371/journal.pone.0101055. [PMID] 24978044.
2014
ERG-APLNR Axis Controls Pulmonary Venule Endothelial Proliferation in Pulmonary Veno-Occlusive Disease
Circulation. 130(14):1179-1191 [DOI] 10.1161/circulationaha.113.007822. [PMID] 25062690.
2014
Flow shear stress enhances intracellular Ca2+signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension
American Journal of Physiology-Cell Physiology. 307(4):C373-C383 [DOI] 10.1152/ajpcell.00115.2014. [PMID] 24920677.
2014
Hypoxia-inducible factor-1α in pulmonary arterial smooth muscle cells and hypoxia-induced pulmonary hypertension.
American journal of respiratory and critical care medicine. 189(3):245-6 [DOI] 10.1164/rccm.201312-2148ED. [PMID] 24484328.
2014
Inhibition of the Ca(2+)-sensing receptor rescues pulmonary hypertension in rats and mice.
Hypertension research : official journal of the Japanese Society of Hypertension. 37(2):116-24 [DOI] 10.1038/hr.2013.129. [PMID] 24089267.
2014
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
American journal of respiratory and critical care medicine. 190(9):1032-43 [DOI] 10.1164/rccm.201401-0121OC. [PMID] 25180446.
2014
The voice of pulmonary circulation.
Pulmonary circulation. 4(1) [DOI] 10.1086/675922. [PMID] 25006415.
2014
Upregulated copper transporters in hypoxia-induced pulmonary hypertension.
PloS one. 9(3) [DOI] 10.1371/journal.pone.0090544. [PMID] 24614111.
2013
[Enhanced Ca2+-sensing receptor function in pulmonary hypertension].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 133(12):1351-9 [PMID] 24292183.
2013
Adenosine monophosphate-activated protein kinase is required for pulmonary artery smooth muscle cell survival and the development of hypoxic pulmonary hypertension.
American journal of respiratory cell and molecular biology. 49(4):609-18 [DOI] 10.1165/rcmb.2012-0446OC. [PMID] 23668615.
2013
Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012.
American journal of respiratory and critical care medicine. 188(3):370-5 [DOI] 10.1164/rccm.201303-0522WS. [PMID] 23713908.
2013
Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2.
American journal of physiology. Lung cellular and molecular physiology. 305(2):L154-64 [DOI] 10.1152/ajplung.00313.2012. [PMID] 23686856.
2013
Current and future therapeutic targets for pulmonary arterial hypertension.
High altitude medicine & biology. 14(2):134-43 [DOI] 10.1089/ham.2013.1007. [PMID] 23795733.
2013
Dihydropyridine Ca 2+ Channel Blockers Increase Cytosolic [Ca 2+ ] by Activating Ca 2+ -sensing Receptors in Pulmonary Arterial Smooth Muscle Cells
Circulation Research. 112(4):640-650 [DOI] 10.1161/circresaha.113.300897. [PMID] 23300272.
2013
Functional characterization of voltage-dependent Ca2+ channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS
American Journal of Physiology-Cell Physiology. 304(11):C1042-C1052 [DOI] 10.1152/ajpcell.00304.2012. [PMID] 23426966.
2013
Human models for smooth muscle cell differentiation. Focus on “A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells”.
American journal of physiology. Cell physiology. 304(4):C287-8 [DOI] 10.1152/ajpcell.00010.2013. [PMID] 23325406.
2013
Hungry for more: autophagy in the pathogenesis of pulmonary arterial hypertension.
Circulation research. 112(8):1091-3 [DOI] 10.1161/CIRCRESAHA.113.301247. [PMID] 23580770.
2013
MicroRNA expression profile of pulmonary artery smooth muscle cells and the effect of let-7d in chronic thromboembolic pulmonary hypertension.
Pulmonary circulation. 3(3):654-64 [DOI] 10.1086/674310. [PMID] 24618550.
2013
Mutant hERG channel traffic jam. Focus on “Pharmacological correction of long QT-linked mutations in KCNH2 (hERG) increases the trafficking of Kv11.1 channels stored in the transitional endoplasmic reticulum”.
American journal of physiology. Cell physiology. 305(9):C916-8 [DOI] 10.1152/ajpcell.00256.2013. [PMID] 23986200.
2013
Optimization of isolated perfused/ventilated mouse lung to study hypoxic pulmonary vasoconstriction.
Pulmonary circulation. 3(2):396-405 [DOI] 10.4103/2045-8932.114776. [PMID] 24015341.
2013
Readership: The heart of Pulmonary Circulation.
Pulmonary circulation. 3(1):1-2 [DOI] 10.4103/2045-8932.109908. [PMID] 23662169.
2013
Risk factors and basic mechanisms of chronic thromboembolic pulmonary hypertension: a current understanding
European Respiratory Journal. 41(2):462-468 [DOI] 10.1183/09031936.00049312. [PMID] 22700839.
2013
Thrombin-mediated activation of Akt signaling contributes to pulmonary vascular remodeling in pulmonary hypertension.
Physiological reports. 1(7) [DOI] 10.1002/phy2.190. [PMID] 24744867.
2013
Transcriptional events during the recovery from MRSA lung infection: a mouse pneumonia model.
PloS one. 8(8) [DOI] 10.1371/journal.pone.0070176. [PMID] 23936388.
2012
“Ether-à-go-go” proliferation of iPSC-derived mesenchymal stem cells. Focus on “Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-à-go-go 1 (hEAG1) potassium channel”.
American journal of physiology. Cell physiology. 303(2):C113-4 [DOI] 10.1152/ajpcell.00160.2012. [PMID] 22572851.
2012
A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease.
American journal of respiratory and critical care medicine. 186(4):359-68 [DOI] 10.1164/rccm.201201-0057OC. [PMID] 22679008.
2012
A one-year-old baby… into the Year of the Dragon.
Pulmonary circulation. 2(1):1-2 [DOI] 10.4103/2045-8932.94815. [PMID] 22558513.
2012
Are men at risk? The role of testosterone in cardiovascular morbidity.
Pulmonary circulation. 2(3):275-7 [DOI] 10.4103/2045-8932.101393. [PMID] 23130097.
2012
CRACing the cluster: functionally active Orai1 channels in the absence of clustering with STIM1.
Circulation research. 111(1):9-11 [DOI] 10.1161/CIRCRESAHA.112.271791. [PMID] 22723218.
2012
Enhanced Ca 2+ -Sensing Receptor Function in Idiopathic Pulmonary Arterial Hypertension
Circulation Research. 111(4):469-481 [DOI] 10.1161/circresaha.112.266361. [PMID] 22730443.
2012
H2S, a gasotransmitter for oxygen sensing in carotid body. Focus on “Endogenous H2S is required for hypoxic sensing by carotid body glomus cells”.
American journal of physiology. Cell physiology. 303(9):C911-2 [DOI] 10.1152/ajpcell.00307.2012. [PMID] 22992680.
2012
Identification of functional progenitor cells in the pulmonary vasculature.
Pulmonary circulation. 2(1):84-100 [DOI] 10.4103/2045-8932.94841. [PMID] 22558524.
2012
New mechanisms of pulmonary arterial hypertension: role of Ca2+signaling
American Journal of Physiology-Heart and Circulatory Physiology. 302(8):H1546-H1562 [DOI] 10.1152/ajpheart.00944.2011. [PMID] 22245772.
2012
Pathogenic role of store-operated and receptor-operated ca(2+) channels in pulmonary arterial hypertension.
Journal of signal transduction. 2012 [DOI] 10.1155/2012/951497. [PMID] 23056939.
2012
PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells.
American journal of physiology. Cell physiology. 302(2):C405-11 [DOI] 10.1152/ajpcell.00337.2011. [PMID] 22031597.
2012
Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation.
The American journal of pathology. 180(6):2268-75 [DOI] 10.1016/j.ajpath.2012.02.016. [PMID] 22632818.
2012
Science is an endless frontier: Encouraging translational research in pulmonary vascular disease.
Pulmonary circulation. 2(2):137-8 [DOI] 10.4103/2045-8932.97585. [PMID] 22837853.
2012
STIM1 restores coronary endothelial function in type 1 diabetic mice.
Circulation research. 111(9):1166-75 [DOI] 10.1161/CIRCRESAHA.112.275743. [PMID] 22896585.
2012
Thyroid hormone receptor-α and vascular function.
American journal of physiology. Cell physiology. 302(9):C1346-52 [DOI] 10.1152/ajpcell.00292.2011. [PMID] 22322976.
2011
Activated expression of cardiac adenylyl cyclase 6 reduces dilation and dysfunction of the pressure-overloaded heart.
Biochemical and biophysical research communications. 405(3):349-55 [DOI] 10.1016/j.bbrc.2010.12.113. [PMID] 21195051.
2011
Activity of Ca -activated Cl channels contributes to regulating receptor- and store-operated Ca entry in human pulmonary artery smooth muscle cells.
Pulmonary circulation. 1(2):269-79 [DOI] 10.4103/2045-8932.83447. [PMID] 22034612.
2011
Adenylyl cyclase 6 improves calcium uptake and left ventricular function in aged hearts.
Journal of the American College of Cardiology. 57(18):1846-55 [DOI] 10.1016/j.jacc.2010.11.052. [PMID] 21527160.
2011
American Journal of Physiology-Cell Physiology theme: ion channels and transporters in cancer.
American journal of physiology. Cell physiology. 301(2):C253-4 [DOI] 10.1152/ajpcell.00159.2011. [PMID] 21613608.
2011
Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant.
Molecular pharmacology. 79(3):381-8 [DOI] 10.1124/mol.110.067298. [PMID] 21127130.
2011
Combination use of sildenafil and simvastatin increases BMPR-II signal transduction in rats with monocrotaline-mediated pulmonary hypertension.
Pulmonary circulation. 1(1):111-4 [DOI] 10.4103/2045-8932.78102. [PMID] 22034597.
2011
Endothelial and Smooth Muscle Cell Ion Channels in Pulmonary Vasoconstriction and Vascular Remodeling
Comprehensive Physiology. 1(3):1555-1602 [DOI] 10.1002/cphy.c100023. [PMID] 23733654.
2011
Fenfluramine-induced gene dysregulation in human pulmonary artery smooth muscle and endothelial cells.
Pulmonary circulation. 1(3):405-18 [DOI] 10.4103/2045-8932.87310. [PMID] 22140631.
2011
Functional Ion Channels in Human Pulmonary Artery Smooth Muscle Cells: Voltage‐Dependent Cation Channels
Pulmonary Circulation. 1(1):48-71 [DOI] 10.4103/2045-8932.78103. [PMID] 21927714.
2011
Our journey continues.
Pulmonary circulation. 1(2) [DOI] 10.4103/2045-8932.83442. [PMID] 22034601.
2011
Pulmonary Circulation : A new venue for communicating your findings, ideas and perspectives.
Pulmonary circulation. 1(1):1-2 [DOI] 10.4103/2045-8932.78094. [PMID] 22034592.
2011
Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels.
Antioxidants & redox signaling. 15(6):1549-65 [DOI] 10.1089/ars.2010.3648. [PMID] 21126186.
2011
STIM2 Contributes to Enhanced Store-operated Ca Entry in Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension.
Pulmonary circulation. 1(1):84-94 [PMID] 21709766.
2011
The world of pulmonary vascular disease.
Pulmonary circulation. 1(3):303-4 [DOI] 10.4103/2045-8932.87291. [PMID] 22140619.
2011
Treatment of Pulmonary Arterial Hypertension
Pulmonary Vascular Disease textbook. (14):695-707 [DOI] ISBN: 978-0-387-87428-9.
2011
VEGF, Bcl-2 and Bad regulated by angiopoietin-1 in oleic acid induced acute lung injury.
Biochemical and biophysical research communications. 413(4):630-6 [DOI] 10.1016/j.bbrc.2011.09.015. [PMID] 21939637.
2010
Combination of sildenafil and simvastatin ameliorates monocrotaline-induced pulmonary hypertension in rats.
Pulmonary pharmacology & therapeutics. 23(5):456-64 [DOI] 10.1016/j.pupt.2010.02.003. [PMID] 20188205.
2010
Idiopathic pulmonary arterial hypertension.
Disease models & mechanisms. 3(5-6):268-73 [DOI] 10.1242/dmm.003616. [PMID] 20427556.
2010
Introduction to TRP channels: structure, function, and regulation.
Advances in experimental medicine and biology. 661:99-108 [DOI] 10.1007/978-1-60761-500-2_6. [PMID] 20204725.
2010
Membrane Receptors, Channels, and Transporters in Pulmonary Circulation
Humana Press-Springer, New York, NY. [DOI] ISBN: 978-1-60761-499-9.
2010
Membrane Receptors, Channels, and Transporters in Pulmonary Circulation
Humana Press Springer. [DOI] ISBN: 978-1-60761-499-9..
2010
Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension.
American journal of physiology. Cell physiology. 298(5):C1217-25 [DOI] 10.1152/ajpcell.00416.2009. [PMID] 20181931.
2010
Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: modulation by protein kinases.
Progress in biophysics and molecular biology. 103(1):95-101 [DOI] 10.1016/j.pbiomolbio.2009.10.001. [PMID] 19835907.
2010
Pulmonary hypertension in China: pulmonary vascular disease: the global perspective.
Chest. 137(6 Suppl):69S-77S [DOI] 10.1378/chest.09-2802. [PMID] 20522582.
2010
Tension Measurement in Isolated Rat and Mouse Pulmonary Artery.
Drug discovery today. Disease models. 7(3-4):123-130 [PMID] 23175638.
2010
Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns
American Journal of Physiology-Cell Physiology. 298(3):C496-C509 [DOI] 10.1152/ajpcell.00464.2009. [PMID] 20018952.
2010
Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension
American Journal of Physiology-Lung Cellular and Molecular Physiology. 298(4):L548-L557 [DOI] 10.1152/ajplung.00314.2009. [PMID] 20139178.
2009
A Functional Single-Nucleotide Polymorphism in theTRPC6Gene Promoter Associated With Idiopathic Pulmonary Arterial Hypertension
Circulation. 119(17):2313-2322 [DOI] 10.1161/circulationaha.108.782458. [PMID] 19380626.
2009
Cellular and Molecular Basis of Pulmonary Arterial Hypertension
Journal of the American College of Cardiology. 54(1):S20-S31 [DOI] 10.1016/j.jacc.2009.04.018. [PMID] 19555855.
2009
Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells.
American journal of physiology. Lung cellular and molecular physiology. 296(6):L979-86 [DOI] 10.1152/ajplung.90412.2008. [PMID] 19363122.
2009
Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells.
Annals of the New York Academy of Sciences. 1177:101-11 [DOI] 10.1111/j.1749-6632.2009.05040.x. [PMID] 19845612.
2009
Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension
American Journal of Physiology-Lung Cellular and Molecular Physiology. 296(6):L870-L878 [DOI] 10.1152/ajplung.90413.2008. [PMID] 19286928.
2009
Inflammation, Growth Factors, and Pulmonary Vascular Remodeling
Journal of the American College of Cardiology. 54(1):S10-S19 [DOI] 10.1016/j.jacc.2009.04.006. [PMID] 19555853.
2009
Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology. 297(4):L666-76 [DOI] 10.1152/ajplung.90548.2008. [PMID] 19633069.
2009
Notch3 signaling promotes the development of pulmonary arterial hypertension
Nature Medicine. 15(11):1289-1297 [DOI] 10.1038/nm.2021. [PMID] 19855400.
2009
Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration.
The Journal of clinical investigation. 119(7):2009-18 [DOI] 10.1172/JCI33338. [PMID] 19487814.
2008
Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling.
Circulation. 117(1):61-9 [PMID] 18071070.
2008
Bringing down the ROS: a new therapeutic approach for PPHN.
American journal of physiology. Lung cellular and molecular physiology. 295(6):L976-8 [DOI] 10.1152/ajplung.90515.2008. [PMID] 18931050.
2008
Characterization of agonist-induced vasoconstriction in mouse pulmonary artery.
American journal of physiology. Heart and circulatory physiology. 294(1):H220-8 [PMID] 17982012.
2008
Downregulation of connexin40 is associated with coronary endothelial cell dysfunction in streptozotocin-induced diabetic mice.
American journal of physiology. Cell physiology. 295(1):C221-30 [DOI] 10.1152/ajpcell.00433.2007. [PMID] 18463230.
2008
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer’s and Parkinson’s diseases.
PloS one. 3(9) [DOI] 10.1371/journal.pone.0003135. [PMID] 18769546.
2008
p75 neurotrophin receptor regulates agonist-induced pulmonary vasoconstriction.
American journal of physiology. Heart and circulatory physiology. 295(4):H1529-38 [DOI] 10.1152/ajpheart.00115.2008. [PMID] 18689502.
2008
Prednisolone inhibits PDGF-induced nuclear translocation of NF-kappaB in human pulmonary artery smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology. 295(4):L648-57 [DOI] 10.1152/ajplung.90245.2008. [PMID] 18708631.
2008
Rac1 promotes intestinal epithelial restitution by increasing Ca2+ influx through interaction with phospholipase C-(gamma)1 after wounding.
American journal of physiology. Cell physiology. 295(6):C1499-509 [DOI] 10.1152/ajpcell.00232.2008. [PMID] 18923057.
2008
Regulation of pulmonary vasoconstriction by agonists and caveolae.
Experimental lung research. 34(4):195-208 [DOI] 10.1080/01902140801925471. [PMID] 18432456.
2008
Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells.
American journal of physiology. Lung cellular and molecular physiology. 295(6):L1048-55 [DOI] 10.1152/ajplung.90259.2008. [PMID] 18836030.
2007
Cardiac L-arginine transport: the CAT is back.
The Journal of physiology. 580(Pt.3):699-700 [PMID] 17363379.
2007
Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI).
Biology of the cell. 99(8):433-44 [PMID] 17388782.
2007
Dynamics of α‐synuclein aggregation and inhibition of pore‐like oligomer development by β‐synuclein
The FEBS Journal. 274(7):1862-1877 [DOI] 10.1111/j.1742-4658.2007.05733.x. [PMID] 17381514.
2007
Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1.
American journal of physiology. Lung cellular and molecular physiology. 292(1):L294-303 [PMID] 16980375.
2007
Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension.
American journal of physiology. Cell physiology. 292(5):C1837-53 [PMID] 17267549.
2007
Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells.
American journal of physiology. Cell physiology. 293(3):C928-37 [PMID] 17581857.
2007
Heterogeneity of hypoxia-mediated decrease inIK(V)and increase in [Ca2+]cytin pulmonary artery smooth muscle cells
American Journal of Physiology-Lung Cellular and Molecular Physiology. 293(2):L402-L416 [DOI] 10.1152/ajplung.00391.2006. [PMID] 17526598.
2007
Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology. 293(4):L952-9 [PMID] 17693484.
2007
Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 21(11):2970-9 [PMID] 17470567.
2007
Point:Counterpoint “Release of an endothelium-derived vasoconstrictor and RhoA/Rho kinase-mediated calcium sensitization of smooth muscle cell contraction are/are not the main effectors for full and sustained hypoxic pulmonary vasoconstriction”.
Journal of applied physiology (Bethesda, Md. : 1985). 102(5) [DOI] 10.1152/japplphysiol.01435.2006. [PMID] 17549820.
2007
Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry.
American journal of physiology. Lung cellular and molecular physiology. 292(5):L1202-10 [PMID] 17189322.
2007
Thiol oxidation causes pulmonary vasodilation by activating K+ channels and inhibiting store-operated Ca2+ channels.
American journal of physiology. Lung cellular and molecular physiology. 292(3):L685-98 [PMID] 17098807.
2007
TRP channels in hypertension.
Biochimica et biophysica acta. 1772(8):895-906 [PMID] 17399958.
2007
Upregulation of Na+/Ca2+ exchanger contributes to the enhanced Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension
American Journal of Physiology-Cell Physiology. 292(6):C2297-C2305 [DOI] 10.1152/ajpcell.00383.2006. [PMID] 17192285.
2006
Acute hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells
American Journal of Physiology-Cell Physiology. 290(3):C907-C916 [DOI] 10.1152/ajpcell.00028.2005. [PMID] 16236819.
2006
Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology. 291(5):L993-1004 [PMID] 16815889.
2006
Histamine-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells.
American journal of physiology. Cell physiology. 290(2):C325-36 [PMID] 16162658.
2006
Molecular biology of chronic thromboembolic pulmonary hypertension.
Seminars in thoracic and cardiovascular surgery. 18(3):265-76 [PMID] 17185190.
2006
Role of O(2)-sensitive K(+) and Ca(2+) channels in the regulation of the pulmonary circulation: potential role of caveolae and implications for high altitude pulmonary edema.
Respiratory physiology & neurobiology. 151(2-3):192-208 [PMID] 16364695.
2006
Transient receptor potential channels and caveolin-1: good friends in tight spaces.
Molecular pharmacology. 70(4):1151-4 [PMID] 16873578.
2006
TRP channels, CCE, and the pulmonary vascular smooth muscle.
Microcirculation (New York, N.Y. : 1994). 13(8):671-92 [PMID] 17085427.
2006
TRPC1 functions as a store-operated Ca2+ channel in intestinal epithelial cells and regulates early mucosal restitution after wounding.
American journal of physiology. Gastrointestinal and liver physiology. 290(4):G782-92 [PMID] 16282360.
2005
Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects.
American journal of physiology. Heart and circulatory physiology. 289(6):H2356-63 [PMID] 16024575.
2005
ClC-3: more than just a volume-sensitive Cl- channel.
British journal of pharmacology. 145(1):1-2 [PMID] 15723095.
2005
Divergent effects of BMP-2 on gene expression in pulmonary artery smooth muscle cells from normal subjects and patients with idiopathic pulmonary arterial hypertension.
Experimental lung research. 31(8):783-806 [DOI] 10.1080/01902140500461026. [PMID] 16368652.
2005
High altitude pulmonary hypertension: role of K+ and Ca2+ channels.
High altitude medicine & biology. 6(2):133-46 [PMID] 16060848.
2005
Hypoxic pulmonary vasoconstriction: role of ion channels.
Journal of applied physiology (Bethesda, Md. : 1985). 98(1):415-20 [PMID] 15591311.
2005
Identification of functional voltage-gated Na+ channels in cultured human pulmonary artery smooth muscle cells
Pflügers Archiv – European Journal of Physiology. 451(2):380-387 [DOI] 10.1007/s00424-005-1478-3. [PMID] 16052353.
2005
Identification of molecular determinants that modulate trafficking of DeltaF508 CFTR, the mutant ABC transporter associated with cystic fibrosis.
Cell biochemistry and biophysics. 42(1):41-53 [PMID] 15673927.
2005
Ion Channels in the Pulmonary Vasculature
Taylor & Francis Group, Boca Raton, Fl. [DOI] ISBN-13: 978-0-8247-5968-1.
2005
Long QT syndrome-associated I593R mutation in HERG potassium channel activates ER stress pathways.
Cell biochemistry and biophysics. 43(3):365-77 [PMID] 16244363.
2005
Pathogenesis of pulmonary arterial hypertension: the need for multiple hits.
Circulation. 111(5):534-8 [PMID] 15699271.
2005
PGE2 and PAR-1 in pulmonary fibrosis: a case of biting the hand that feeds you?
American journal of physiology. Lung cellular and molecular physiology. 288(5):L789-92 [PMID] 15821019.
2005
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages
Nature. 433(7026):647-653 [DOI] 10.1038/nature03215. [PMID] 15703750.
2005
Role of Na+/Ca2+ exchange in regulating cytosolic Ca2+ in cultured human pulmonary artery smooth muscle cells.
American journal of physiology. Cell physiology. 288(2):C245-52 [PMID] 15456699.
2004
Activation of K+channels: an essential pathway in programmed cell death
American Journal of Physiology-Lung Cellular and Molecular Physiology. 286(1):L49-L67 [DOI] 10.1152/ajplung.00041.2003. [PMID] 14656699.
2004
ATP-induced mitogenesis is mediated by cyclic AMP response element-binding protein-enhanced TRPC4 expression and activity in human pulmonary artery smooth muscle cells.
American journal of physiology. Cell physiology. 287(5):C1192-201 [PMID] 15229105.
2004
Bosentan Inhibits Transient Receptor Potential Channel Expression in Pulmonary Vascular Myocytes
American Journal of Respiratory and Critical Care Medicine. 170(10):1101-1107 [DOI] 10.1164/rccm.200312-1668oc. [PMID] 15317671.
2004
Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation.
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society. 19:44-50 [PMID] 15016901.
2004
Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension
Microvascular Research. 68(2):75-103 [DOI] 10.1016/j.mvr.2004.06.001. [PMID] 15313118.
2004
Diversity of voltage-dependent K+ channels in human pulmonary artery smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology. 287(1):L226-38 [PMID] 15047570.
2004
Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension
Proceedings of the National Academy of Sciences. 101(38):13861-13866 [DOI] 10.1073/pnas.0405908101. [PMID] 15358862.
2004
Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms
Kluwer Academic . [DOI] ISBN: 978-1-4020-7857-6.
2004
Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms
Kluwer Academic Publishers. [DOI] ISBN 7-80132-994-5.
2004
Molecular biology of primary pulmonary hypertension.
Cardiology clinics. 22(3):417-29, vi [PMID] 15302361.
2004
Overexpression of humanKCNA5increasesIK(V)and enhances apoptosis
American Journal of Physiology-Cell Physiology. 287(3):C715-C722 [DOI] 10.1152/ajpcell.00050.2004. [PMID] 15140747.
2004
Overexpression of TRPC1 enhances pulmonary vasoconstriction induced by capacitative Ca2+ entry.
American journal of physiology. Lung cellular and molecular physiology. 287(5):L962-9 [PMID] 15220115.
2003
Apoptosis repressor with caspase domain inhibits cardiomyocyte apoptosis by reducing K+ currents.
American journal of physiology. Cell physiology. 284(6):C1405-10 [PMID] 12734105.
2003
Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells.
American journal of physiology. Lung cellular and molecular physiology. 285(3):L740-54 [PMID] 12740218.
2003
Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2+ entry in human pulmonary artery endothelial cells.
American journal of physiology. Lung cellular and molecular physiology. 285(6):L1233-45 [PMID] 12909593.
2003
PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression.
American journal of physiology. Cell physiology. 284(2):C316-30 [PMID] 12529250.
2003
Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution.
American journal of physiology. Cell physiology. 284(4):C848-59 [PMID] 12466151.
2003
Signaling molecules in nonfamilial pulmonary hypertension.
The New England journal of medicine. 348(6):500-9 [PMID] 12571257.
2002
Activation of K(+) channels and increased migration of differentiated intestinal epithelial cells after wounding.
American journal of physiology. Cell physiology. 282(4):C885-98 [PMID] 11880277.
2002
Cytochrome c activates K+ channels before inducing apoptosis.
American journal of physiology. Cell physiology. 283(4):C1298-305 [PMID] 12225992.
2002
Role of capacitative Ca2+ entry in bronchial contraction and remodeling.
Journal of applied physiology (Bethesda, Md. : 1985). 92(4):1594-602 [PMID] 11896026.
2001
Activation of K+channels induces apoptosis in vascular smooth muscle cells
American Journal of Physiology-Cell Physiology. 280(4):C970-C979 [DOI] 10.1152/ajpcell.2001.280.4.c970. [PMID] 11748062.
2001
Anorexic effect of K+channel blockade in mesenteric arterial smooth muscle and intestinal epithelial cells
Journal of Applied Physiology. 91(5):2322-2333 [DOI] 10.1152/jappl.2001.91.5.2322.
2001
Bcl-2 decreases voltage-gated K+channel activity and enhances survival in vascular smooth muscle cells
American Journal of Physiology-Cell Physiology. 281(1):C157-C165 [DOI] 10.1152/ajpcell.2001.281.1.c157.
2001
c-Jun Decreases Voltage-Gated K + Channel Activity in Pulmonary Artery Smooth Muscle Cells
Circulation. 104(13):1557-1563 [DOI] 10.1161/hc3801.095662.
1998
Action of fenfluramine on voltage- gated K+ channels in human pulmonary-artery smooth-muscle cells
The Lancet. 352(9124) [DOI] 10.1016/s0140-6736(05)60264-4.
1998
Attenuated K+ channel gene transcription in primary pulmonary hypertension
The Lancet. 351(9104):726-727 [DOI] 10.1016/s0140-6736(05)78495-6.
1998
Dysfunctional Voltage-Gated K + Channels in Pulmonary Artery Smooth Muscle Cells of Patients With Primary Pulmonary Hypertension
Circulation. 98(14):1400-1406 [DOI] 10.1161/01.cir.98.14.1400.
1998
Molecular basis and function of voltage-gated K+channels in pulmonary arterial smooth muscle cells
American Journal of Physiology-Lung Cellular and Molecular Physiology. 274(4):L621-L635 [DOI] 10.1152/ajplung.1998.274.4.l621.
1997
Hypoxia inhibits gene expression of voltage-gated K+ channel alpha subunits in pulmonary artery smooth muscle cells.
Journal of Clinical Investigation. 100(9):2347-2353 [DOI] 10.1172/jci119774.
1997
Role of calcium-activated chloride current in regulating pulmonary vasomotor tone
American Journal of Physiology-Lung Cellular and Molecular Physiology. 272(5):L959-L968 [DOI] 10.1152/ajplung.1997.272.5.l959.
1996
NO hyperpolarizes pulmonary artery smooth muscle cells and decreases the intracellular Ca2+ concentration by activating voltage-gated K+ channels.
Proceedings of the National Academy of Sciences. 93(19):10489-10494 [DOI] 10.1073/pnas.93.19.10489. [PMID] 8816828.
1995
Voltage-Gated K + Currents Regulate Resting Membrane Potential and [Ca 2+ ] i in Pulmonary Arterial Myocytes
Circulation Research. 77(2):370-378 [DOI] 10.1161/01.res.77.2.370.
1993
Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes
American Journal of Physiology-Lung Cellular and Molecular Physiology. 264(2):L116-L123 [DOI] 10.1152/ajplung.1993.264.2.l116.
1990
Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries
American Journal of Physiology-Heart and Circulatory Physiology. 259(2):H281-H289 [DOI] 10.1152/ajpheart.1990.259.2.h281.
1986
Building a helpful relationship: the foundation of effective patient education.
The Diabetes educator. 12(4):374-8 [PMID] 3640700.
1976
Briefly Noted
Religious Education. 71(5):518-518, 529, 559 [DOI] 10.1080/0034408760710513.
218
Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition
Am. J. Physiol. Lung Cell. Mol. Physiol. (314):L256-L275

Education

Ph.D.
1993 · Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China
M.D.
1983 · Suzhou Medical College, Suzhou, China

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