Sathyanarayanan V Puthanveettil, Ph.D.
Associate Professor
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About Sathyanarayanan V Puthanveettil
Dr. Puthanveettil graduated from Washington State University where he studied calcium calmodulin dependent protein kinases in the laboratory of Dr. B. W. Poovaiah. He then joined Dr. Eric Kandel’s laboratory at the Howard Hughes Medical Institute, Columbia University, for his post-doctoral research on learning and memory storage.
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Associate Professor, Department of Neuroscience
2015 – Current · Scripps Research
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Faculty member, Kellog School of Science and Technology
2011 – 2011 · The Scripps Research Institute
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Adjunct faculty, Department of Biological Sciences
2011 – 2011 · Florida Atlantic University
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Adjunct faculty, Department of Biomedical Sciences
2011 – 2011 · Charles E. Schmidt School of Medicine, FAU
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Assistant Professor, Department of Neuroscience
2010 – 2014 · Scripps Florida
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Associate Research Scientist, Eric Kandel Laboratory
2006 – 2006 · Columbia University Medical Center
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HHMI Research Associate/Postdoctoral Research Scientist
2001 – 2006 · Eric Kandel Laboratory, Columbia University Medical Center
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Graduate Research Assistant
1996 – 2001 · Poovaiah laboratory, Washington State University, Pullman
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Visiting Scientist
1995 – 1996 · Rice Genome Research Program, STAFF Institute
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Research Assistant, International Center for Genetic Engineering and Biotechnology (ICGEB)
1994 – 1996 · United Nations Industrial Developmental Organization
Accomplishments
Research Profile
Molecular Logic For The Storage and Maintenance Of Long-Term Memory
The long-term goal of my laboratory is to understand the molecular and cellular basis of memory storage and cognitive disorders. At the cellular level there are two hallmarks of long-term memory storage: experience-dependent activation of gene expression in the nucleus, and local activation of translation at specific synapses.
Previously I have demonstrated in Eric Kandel’s laboratory that activation of fast axonal transport in pre- and post- synaptic neurons during learning is another critical component of long-term memory storage. Activation of molecular transport to synapses is a rate limiting step and coordinates nuclear and synaptic processes during memory storage. The transported cargos include organelles, proteins, mRNAs, and noncoding RNAs.
In an effort to learn what gene products are transported in specific neurons in response to activity, how they are transported, how they are stored for later use, and eventually when and how they are utilized at specific synapses during learning and memory storage, my laboratory uses an integrated approach that combines several high throughput techniques such as genomics and proteomics with electrophysiology, biochemistry, and imaging. A comprehensive understanding of transported cargos will help us in elucidating signaling pathways at the synapse and mechanisms underlying synaptic dysfunction. Animal models such as Aplysia and mice are used to tackle these questions at the cellular and systems levels. In addition, we explore these questions using mouse models for cognitive disorders such as Alzheimer’s and Huntington’s disease.
0000-0002-1302-6766
Publications
Academic Articles
Grants
Education
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Ph.D. in Biochemistry/Biophysics
Washington State University
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Master’s of Science in Biotechnology
Tamil Nadu Agricultural University
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Bachelor’s of Science in Agriculture
Kerala Agricultural University
Contact Details
- Business:
- (561) 228-2243
- Business:
- sputhanveettil@ufl.edu
- Business Mailing:
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Location C343
130 SCRIPPS WAY BLDG 3C2
JUPITER FL 33458