Matthew Pipkin, Ph.D.
Associate Professor
On This Page
About Matthew Pipkin
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Associate Professor, Cancer Biology
2014 – 2017 · Scripps Research
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Associate Professor (Joint Appointment), Immunology and Microbial Science (IMS)
2014 – 2017 · Scripps Research
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Assistant Professor, Cancer Biology
2012 – 2014 · Scripps Research
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Assistant Professor (Joint Appointment), Immunology and Microbial Science (IMS)
2012 – 2014 · Scripps Research
Research Profile
The overall focus of the Pipkin lab is to elucidate how chromatin structure and transcription controls the gene expression programs that establish and maintain the differentiated states of T cells. The lab specifically studies how naïve CD8 T cells differentiate into effector and memory cytotoxic T lymphocytes (CTL). CTL are killer lymphocytes that hold outstanding promise for controlling viral infections and cancer therapeutically, as they can be employed in adoptive immunotherapy and are the target of successful vaccination. The Pipkin lab has developed novel approaches to map the fundamental repeating structures of chromatin (nucleosomes) at unprecedented resolution, novel reporter genes to track cells in vivo that induce expression of Prf1, an essential gene that is required for the anti-tumor killing activity of CTL, and the only systems to conduct genome-scale pooled RNAi screens in T cells, in vivo, during the course of actual viral infections. Using these tools and approaches, the Pipkin lab is clarifying how transcription factors govern the specific organization of nucleosomes that enforces CTL differentiation, identifying the chromatin regulatory factors that maintain the differentiated state epigenetically, and demonstrating how these processes mediate durable immunity.
0000-0002-9688-0190
Publications
Academic Articles
Grants
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Understanding RNase L Deactivation and Promotion of Cellular Immunity
Active
- Role:
- Other
- Funding:
- NATL INST OF HLTH NIAID
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Elucidating the Origins and Drivers of Multipotency in CD8 T cell Memory
- Role:
- Other
- Funding:
- AMER HEART ASSOCIATION
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Nuclear Receptor Networks in Mucosal Immune Regulation
- Role:
- Principal Investigator
- Funding:
- DARTMOUTH-HITCHCOCK MEMORIAL CNTR via NATL INST OF HLTH NIAID
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Elucidating the epigenetic landscape of neurofibromatosis and development of therapeutic targets
- Role:
- Principal Investigator
- Funding:
- H LEE MOFFITT CANCER CTR & RES INST via NATL INST OF HLTH NINDS
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Transcription factor regulation of CD4 and CD8 T cell effector and memory differentiation and function
- Role:
- Principal Investigator
- Funding:
- NATL INST OF HLTH NIAID
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Identification and characterization of chromatin regulators of HIV-1 latency
- Role:
- Co-Investigator
- Funding:
- NATL INST OF HLTH NIAID
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Nuclear Receptor Networks in Mucosal Immune Regulation
- Role:
- Principal Investigator
- Funding:
- NATL INST OF HLTH NIAID
Education
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Ph.D. in Microbiology and Immunology
University of Miami, School of Medicine
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Bachelor’s of Science in Microbiology and Immunology
University of Miami
Contact Details
- Business:
- (561) 228-2182
- Business:
- m.pipkin@ufl.edu
- Business Mailing:
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Location C243
130 SCRIPPS WAY BLDG, 2C2
JUPITER FL 33458