Mauricio Martins

Mauricio Martins, Ph.D.

Associate Professor

Department: SR-IM-MARTINS LAB
Business Phone: (561) 228-3051
Business Email: mauricio.martins@ufl.edu

Accomplishments

Vaccine’s Young Investigator
2016 ·

Research Profile

I am interested in developing practical immune interventions against globally relevant human pathogens. HIV is the current topic of my research. My group is using rhesus macaque models of HIV/AIDS to develop active and passive immunization strategies for preventing and treating HIV infection.

Open Researcher and Contributor ID (ORCID)

0000-0001-8336-216X

Publications

2023
Adeno-associated virus-vectored delivery of HIV biologics: the promise of a “single-shot” functional cure for HIV infection
Journal of Virus Eradication. 9(1) [DOI] 10.1016/j.jve.2023.100316. [PMID] 36915910.
2021
Effector function does not contribute to protection from virus challenge by a highly potent HIV broadly neutralizing antibody in nonhuman primates
Science Translational Medicine. 13(585) [DOI] 10.1126/scitranslmed.abe3349. [PMID] 33731434.
2021
Recombinant Herpesvirus Vectors: Durable Immune Responses and Durable Protection against Simian Immunodeficiency Virus SIVmac239 Acquisition
Journal of Virology. 95(14) [DOI] 10.1128/jvi.00330-21.
2020
A Recombinant Rhesus Monkey Rhadinovirus Deleted of Glycoprotein L Establishes Persistent Infection of Rhesus Macaques and Elicits Conventional T Cell Responses
Journal of Virology. 94(2) [DOI] 10.1128/jvi.01093-19.
2020
Rectal Acquisition of Simian Immunodeficiency Virus (SIV) SIVmac239 Infection despite Vaccine-Induced Immune Responses against the Entire SIV Proteome
Journal of Virology. 94(24) [DOI] 10.1128/jvi.00979-20.
2019
The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08 + Rhesus Macaques
Journal of Virology. 93(5) [DOI] 10.1128/jvi.01626-18.
2019
Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques
PLOS Pathogens. 15(9) [DOI] 10.1371/journal.ppat.1008015. [PMID] 31568531.
2018
Mamu-B*17 + Rhesus Macaques Vaccinated with env , vif , and nef Manifest Early Control of SIVmac239 Replication
Journal of Virology. 92(16) [DOI] 10.1128/jvi.00690-18.
2018
A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products
PLOS Pathogens. 14(6) [DOI] 10.1371/journal.ppat.1007143. [PMID] 29912986.
2017
Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques
Science Translational Medicine. 9(410) [DOI] 10.1126/scitranslmed.aan8184. [PMID] 28978754.
2017
Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques
PLOS Pathogens. 13(7) [DOI] 10.1371/journal.ppat.1006529. [PMID] 28732035.

Grants

Sep 2023 ACTIVE
LNP Delivery of DNA-Encoded eCD4-Ig
Role: Principal Investigator
Funding: EMMUNE via BILL & MELINDA GATES FOUNDATION
Apr 2023 ACTIVE
An AAV-mediated functional cure and its impact on the reservoir
Role: Principal Investigator
Funding: BOSTON CHILDRENS HOSPITAL via NATL INST OF HLTH NIAID
Dec 2022 ACTIVE
Overcoming pre-existing immunity to AAV to enhance AAV-based HIV immunotherapies
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Sep 2022 – Jun 2023
Costimulation Blockade for Preventing Anti-Drug Antibody Responses Following AAV-Mediated Gene Therapy with Anti-HIV bnAb
Role: Principal Investigator
Funding: UNIV OF MIAMI via FL DEPT OF HLTH
Apr 2022 ACTIVE
Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney Collaboratory
Role: Principal Investigator
Funding: JOHNS HOPKINS UNIVERSITY via NATL INST OF HLTH NIAID
Apr 2022 ACTIVE
AAV-mediated delivery of eCD4-Ig for prevention and treatment of perinatal HIV infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Apr 2022 ACTIVE
eCD4-Ig for preventing and treating obstetric HIV infection
Role: Principal Investigator
Funding: NATL INST OF HLTH NICHD
Apr 2022 – Feb 2023
An AAV-mediated functional cure and its impact on the reservoir
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Apr 2022 – Nov 2022
A nonhuman primate model to study the immunological effects of feminizing hormone therapy in transgender women
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID

Contact Details

Phones:
Business:
(561) 228-3051
Emails:
Addresses:
Business Mailing:
Location C221
130 SCRIPPS WAY BLDG, 2B2
JUPITER FL 33458