Ryoma Hattori

Ryoma Hattori, Ph.D.

Assistant Professor

Department: SR-NEURO-HATTORI LAB
Business Phone: (561) 228-2657
Business Email: rhattori@ufl.edu

About Ryoma Hattori

Additional Positions:
Assistant Project Scientist
2022 – 2023 · University of California San Diego
Postdoctoral Scholar
2016 – 2022 · University of California San Diego
Related Links:

Accomplishments

SFARI Bridge-to-Independence Award
2022-Current · Simons Foundation
Warren Alpert Distinguished Scholar Award
2021-Current · Warren Alpert Foundation
Postdoctoral Grant Award
2021-2022 · The KANAE Foundation for the Promotion of Medical Science
Postdoctoral Fellowship
2019-2021 · Japan Society for the Promotion of Science
Postdoctoral Fellowship
2018-2019 · The Uehara Memorial Foundation postdoctoral fellowship
Graduate Student Fellowship
2010-2015 · The Nakajima Foundation

Research Profile

Our laboratory focuses on understanding the neural mechanisms for decision making, reinforcement learning, and number sense in healthy and disease states. We investigate these mechanisms through large-scale recordings of neural activity and synaptic plasticity dynamics from mice engaged in sophisticated head-fixed behavior tasks. We employ data science approaches, including the use of AI, to analyze and simulate animal behaviors and neural network dynamics.

Reinforcement learning (RL) is a trial-and-error learning that involves interactions with an environment. Through the interactions, animals learn optimal behaviors by reinforcing actions that lead to rewarding events and avoiding actions that lead to undesired outcomes. RL has been also very powerful in training artificial intelligence (AI), enabling AI to outperform humans in complex tasks. Understanding of the neural mechanisms of RL facilitates not only the development of treatment for learning and cognitive impairments but also development of novel RL approach in the field of AI. However, the underlying neural mechanisms are complex because the processes involve many brain areas. We investigate how different brain areas interact to process the computations that are necessary for the RL and its associated value-based decision making, and how these processes may be impaired in neurological disorders.

Another research project in our lab focuses on the neural mechanisms for number sense. Number is an important concept in our daily lives as humans. However, the neural mechanisms for number sense have been poorly understood. We will investigate how number information is processed in the brain and how such system could be impaired in neurological disorders.

Open Researcher and Contributor ID (ORCID)

0000-0002-4908-4933

Publications

2023
Exponential history integration with diverse temporal scales in retrosplenial cortex supports hyperbolic behavior
Science Advances. 9(48) [DOI] 10.1126/sciadv.adj4897. [PMID] 38019904.
2023
Meta-reinforcement learning via orbitofrontal cortex
Nature Neuroscience. 26(12):2182-2191 [DOI] 10.1038/s41593-023-01485-3. [PMID] 37957318.
2023
Super-Resolution With Binary Priors: Theory and Algorithms
IEEE Transactions on Signal Processing. 71:3213-3228 [DOI] 10.1109/tsp.2023.3260564.
2022
Context-dependent persistency as a coding mechanism for robust and widely distributed value coding.
Neuron. 110(3):502-515.e11 [DOI] 10.1016/j.neuron.2021.11.001. [PMID] 34818514.
2022
Longitudinal two-photon calcium imaging with ultra-large cranial window for head-fixed mice.
STAR protocols. 3(2) [DOI] 10.1016/j.xpro.2022.101343. [PMID] 35496806.
2022
PatchWarp: Corrections of non-uniform image distortions in two-photon calcium imaging data by patchwork affine transformations.
Cell reports methods. 2(5) [DOI] 10.1016/j.crmeth.2022.100205. [PMID] 35637910.
2019
Area-Specificity and Plasticity of History-Dependent Value Coding During Learning.
Cell. 177(7):1858-1872.e15 [DOI] 10.1016/j.cell.2019.04.027. [PMID] 31080067.
2019
Decoding ECoG High Gamma Power from Cellular Calcium Response using Transparent Graphene Microelectrodes
2019 9th International IEEE/EMBS Conference on Neural Engineering (NER). [DOI] 10.1109/ner.2019.8717147.
2018
Ultra-low Impedance Graphene Microelectrodes with High Optical Transparency for Simultaneous Deep 2-photon Imaging in Transgenic Mice.
Advanced functional materials. 28(31) [DOI] 10.1002/adfm.201800002. [PMID] 34084100.
2017
Developmental dynamics of cross-modality in mouse visual cortex
bioRxiv. [DOI] 10.1101/150847 .
2017
Enhanced cross-modal activation of sensory cortex in mouse models of autism
bioRxiv. [DOI] 10.1101/150839 .
2017
Functions and dysfunctions of neocortical inhibitory neuron subtypes.
Nature neuroscience. 20(9):1199-1208 [DOI] 10.1038/nn.4619. [PMID] 28849791.

Grants

Oct 2023 ACTIVE
Neural mechanisms of meta-reinforcement learning
Role: Principal Investigator
Funding: WARREN ALPERT FOUNDATION

Education

Ph.D. in Molecular and Cellular Biology
2016 · Harvard University
A.M. in Molecular and Cellular Biology
2012 · Harvard University
B.S. in Biophysics and Biochemistry
2010 · University of Tokyo

Contact Details

Phones:
Business:
(561) 228-2657
Emails:
Business:
rhattori@ufl.edu
Addresses:
Business Street:
130 SCRIPPS WAY # 3B3
JUPITER FL 33458