Joe G.N. Garcia, MD

Joe G.N. Garcia, MD,

ASSOCIATE VICE PRESIDENT For RESEARCH

Department: SR-MM-GARCIA LAB
Business Phone: (561) 228-2030
Business Email: jgn.garcia@ufl.edu

About Joe G.N. Garcia, MD

Dr. Joe G. N. “Skip” Garcia is a renowned pulmonary physician-scientist and a distinguished figure in the field of medicine. He currently holds several prestigious positions, including being an endowed professor and the Director of the Center for Inflammation Sciences and Systems Medicine at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology. Additionally, he serves as the Associate Vice President of Research at the University of Florida. Dr. Garcia’s contributions to the medical community have been recognized by his election as a member of the National Academy of Medicine.

Dr. Garcia’s expertise lies in the genetic basis of lung disease and the prevention and treatment of inflammatory lung injury. He is widely acknowledged for his groundbreaking work in developing novel biomarkers and therapies for critically ill patients affected by acute inflammatory lung disease. Furthermore, Dr. Garcia’s research efforts extend to addressing health disparities among vulnerable populations. His remarkable achievements are evident in his extensive publication record, which includes over 575 peer-reviewed publications. Dr. Garcia’s dedication to advancing medical knowledge is reflected in his leadership of large federally-funded programs and his impressive portfolio of NIH-sponsored research.

Additional Positions:
Director
2023 – Current · Center for Inflammation Sciences & Systems Medicine, UF Scripps
Professor of Medicine
2023 – Current · University of Florida

Research Profile

Dr. Garcia’s expertise extends to the genetic basis of inflammatory lung disease, with a particular focus on health disparities, as well as the mechanistic understanding of lung vascular permeability. Through bench-to-bedside approaches, his laboratory has conducted innovative research to develop methods aimed at preventing vascular leak, restoring endothelial cell barrier function, and maintaining vascular integrity.

Given their deep knowledge of lung inflammation and vascular permeability, Dr. Garcia’s lab has also explored the role of lung vasculature in the development of lung metastases. Leveraging their expertise in genomics, they have identified vascular genes that are crucial participants in both inflammatory lung injury and cancer development. Their investigations have led to the development of lung endothelial inflammatory gene expression profiles and diagnostic gene signatures influenced by key genes such as MYLK and NAMPT, which have implications for lung and breast cancer prognosis.

Furthermore, their work with NAMPT has resulted in the development of a therapeutic NAMPT neutralizing antibody. This antibody has shown promise in treating various cancers, including lung cancer, melanoma, and chronic lymphocytic leukemia.

Additionally, Dr. Garcia’s laboratory is actively involved in studying the adverse effects of thoracic radiation and exploring strategies to mitigate radiation-induced pneumonitis, fibrosis, and vascular leak.

Open Researcher and Contributor ID (ORCID)

0000-0002-6934-0420

Publications

2024
Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension
Circulation. [DOI] 10.1161/circulationaha.123.065304.
2024
Development of a cloud-based flow rate tool for eNAMPT biomarker detection
PNAS Nexus. 3(5) [DOI] 10.1093/pnasnexus/pgae173. [PMID] 38711808.
2024
Extracellular Nicotinamide Phosphoribosyltransferase Is a Therapeutic Target in Experimental Necrotizing Enterocolitis
Biomedicines. 12(5) [DOI] 10.3390/biomedicines12050970.
2023
A Least Absolute Shrinkage and Selection Operator-Derived Predictive Model for Postoperative Respiratory Failure in a Heterogeneous Adult Elective Surgery Patient Population
CHEST Critical Care. 1(3) [DOI] 10.1016/j.chstcc.2023.100025. [PMID] 38434477.
2023
Classification and Predictors of Right Ventricular Functional Recovery in Pulmonary Arterial Hypertension
Circulation: Heart Failure. 16(10) [DOI] 10.1161/circheartfailure.123.010555.
2023
Development of a peripheral blood transcriptomic gene signature to predict bronchopulmonary dysplasia
American Journal of Physiology-Lung Cellular and Molecular Physiology. 324(1):L76-L87 [DOI] 10.1152/ajplung.00250.2022. [PMID] 36472344.
2023
eNAMPT/TLR4 inflammatory cascade activation is a key contributor to SLE Lung vasculitis and alveolar hemorrhage
Journal of Translational Autoimmunity. 6 [DOI] 10.1016/j.jtauto.2022.100181. [PMID] 36619655.
2023
Involvement of eNAMPT/TLR4 inflammatory signaling in progression of non‐alcoholic fatty liver disease, steatohepatitis, and fibrosis
The FASEB Journal. 37(3) [DOI] 10.1096/fj.202201972rr.
2023
Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity
Therapeutic Advances in Respiratory Disease. 17 [DOI] 10.1177/17534666231181262. [PMID] 37477094.
2023
NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8
Science Advances. 9(5) [DOI] 10.1126/sciadv.ade9585. [PMID] 36724221.
2023
Targeting SELPLG/P‐selectin glycoprotein ligand 1 in preclinical ARDS: Genetic and epigenetic regulation of the SELPLG promoter
Pulmonary Circulation. 13(1) [DOI] 10.1002/pul2.12206. [PMID] 36873461.
2022
Cortactin in Lung Cell Function and Disease
International Journal of Molecular Sciences. 23(9) [DOI] 10.3390/ijms23094606. [PMID] 35562995.
2022
Critical role for the lung endothelial nonmuscle myosin light‐chain kinase isoform in the severity of inflammatory murine lung injury
Pulmonary Circulation. 12(2) [DOI] 10.1002/pul2.12061. [PMID] 35514774.
2022
eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-induced Lung Fibrosis
American Journal of Respiratory Cell and Molecular Biology. 66(5):497-509 [DOI] 10.1165/rcmb.2021-0357oc.
2022
MRSA-induced endothelial permeability and acute lung injury are attenuated by FTY720 S-phosphonate
American Journal of Physiology-Lung Cellular and Molecular Physiology. 322(1):L149-L161 [DOI] 10.1152/ajplung.00100.2021. [PMID] 35015568.
2021
Cohesive cancer invasion of the biophysical barrier of smooth muscle
Cancer and Metastasis Reviews. 40(1):205-219 [DOI] 10.1007/s10555-020-09950-2. [PMID] 33398621.
2021
Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT‐neutralizing mAb
Pulmonary Circulation. 11(4):1-14 [DOI] 10.1177/20458940211059712. [PMID] 34790349.
2021
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension
American Journal of Physiology-Cell Physiology. 321(6):C1010-C1027 [DOI] 10.1152/ajpcell.00147.2021. [PMID] 34669509.
2021
EVL is a novel focal adhesion protein involved in the regulation of cytoskeletal dynamics and vascular permeability
Pulmonary Circulation. 11(4):1-10 [DOI] 10.1177/20458940211049002. [PMID] 34631011.
2021
Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress
Clinical Science. 135(7):963-977 [DOI] 10.1042/cs20201448.
2021
Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis
European Respiratory Journal. 58(6) [DOI] 10.1183/13993003.02950-2020. [PMID] 34083402.
2021
TRPC6, a therapeutic target for pulmonary hypertension
American Journal of Physiology-Lung Cellular and Molecular Physiology. 321(6):L1161-L1182 [DOI] 10.1152/ajplung.00159.2021. [PMID] 34704831.
2020
Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α
American Journal of Respiratory Cell and Molecular Biology. 63(1):92-103 [DOI] 10.1165/rcmb.2019-0164oc.
2020
Endothelial platelet‐derived growth factor‐mediated activation of smooth muscle platelet‐derived growth factor receptors in pulmonary arterial hypertension
Pulmonary Circulation. 10(3):1-15 [DOI] 10.1177/2045894020948470. [PMID] 33294172.
2020
Sphingosine‐1‐phosphate receptor‐independent lung endothelial cell barrier disruption induced by FTY720 regioisomers
Pulmonary Circulation. 10(1):1-10 [DOI] 10.1177/2045894020905521. [PMID] 32095229.
2018
Single nucleotide polymorphisms in the MYLKP1 pseudogene are associated with increased colon cancer risk in African Americans
PLOS ONE. 13(8) [DOI] 10.1371/journal.pone.0200916. [PMID] 30161129.

Grants

Apr 2024 ACTIVE
Novel Involvement of NAMPT and TLR4 in PAH Vascular Remodeling
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Sep 2023 ACTIVE
Cytoskeletal Regulation of Lung Endothelial Pathobiology in ARDS
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Aug 2023 ACTIVE
Novel mechanism for eNAMPT secretion in PAH vascular remodeling
Role: Other
Funding: NATL INST OF HLTH NIA
Apr 2023 – Mar 2024
Validation of a Genetic-based Biomarker Panel for Stratification of Mortality Risk in ARDS Patients
Role: Principal Investigator
Funding: UNIVERSITY OF ARIZONA via NATL INST OF HLTH NHLBI
Jan 2023 ACTIVE
Coronary Microvascular Disease in Diabetes: Role of NAMPT
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA SAN DIEGO via US ARMY MED RES ACQUISITION

Contact Details

Phones:
Business:
(561) 228-2030
Emails:
Business:
jgn.garcia@ufl.edu
Manager, Administrative Services:
Addresses:
Business Street:
130 SCRIPPS WAY
JUPITER FL 33458