James Burke,
AST PROF
About James Burke
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Publications
Academic Articles
2024
RNase L-induced bodies sequester subgenomic flavivirus RNAs and re-establish host RNA decay.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.03.25.586660.
[PMID] 38585896.
2023
Single-cell analysis of RNase L-mediated mRNA decay.
Methods in enzymology.
692:157-175
[DOI] 10.1016/bs.mie.2023.04.016.
[PMID] 37925178.
2022
Adherence to Antiseizure vs Other Medications Among US Medicare Beneficiaries With and Without Epilepsy.
Neurology.
98(4):e427-e436
[DOI] 10.1212/WNL.0000000000013119.
[PMID] 34893556.
2022
dsRNA-induced condensation of antiviral proteins modulates PKR activity.
Proceedings of the National Academy of Sciences of the United States of America.
119(33)
[DOI] 10.1073/pnas.2204235119.
[PMID] 35939694.
2022
Novel stress granule-like structures are induced via a paracrine mechanism during viral infection.
Journal of cell science.
135(4)
[DOI] 10.1242/jcs.259194.
[PMID] 35098996.
2022
Regulation of ribonucleoprotein condensates by RNase L during viral infection.
Wiley interdisciplinary reviews. RNA.
14(4)
[DOI] 10.1002/wrna.1770.
[PMID] 36479619.
2022
RNA is required for the integrity of multiple nuclear and cytoplasmic membrane-less RNP granules.
The EMBO journal.
41(9)
[DOI] 10.15252/embj.2021110137.
[PMID] 35355287.
2022
RNase L activation in the cytoplasm induces aberrant processing of mRNAs in the nucleus.
PLoS pathogens.
18(11)
[DOI] 10.1371/journal.ppat.1010930.
[PMID] 36318584.
2021
ADAR1 limits stress granule formation through both translation-dependent and translation-independent mechanisms.
Journal of cell science.
134(17)
[DOI] 10.1242/jcs.258783.
[PMID] 34397095.
2021
Cardiovascular disease risk, awareness, and treatment in people with epilepsy.
Epilepsy & behavior : E&B.
117
[DOI] 10.1016/j.yebeh.2021.107878.
[PMID] 33690068.
2021
Rapid decay of host basal mRNAs during SARS-CoV-2 infection perturbs host antiviral mRNA biogenesis and export.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2021.04.19.440452.
[PMID] 33907748.
2021
RNase L limits host and viral protein synthesis via inhibition of mRNA export.
Science advances.
7(23)
[DOI] 10.1126/sciadv.abh2479.
[PMID] 34088676.
2021
SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block.
RNA (New York, N.Y.).
27(11):1318-1329
[DOI] 10.1261/rna.078923.121.
[PMID] 34315815.
2021
Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening.
Science advances.
7(1)
[DOI] 10.1126/sciadv.abd5393.
[PMID] 33219112.
2020
DUSP11-mediated control of 5′-triphosphate RNA regulates RIG-I sensitivity.
Genes & development.
34(23-24):1697-1712
[DOI] 10.1101/gad.340604.120.
[PMID] 33184222.
2020
Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation.
PLoS pathogens.
16(1)
[DOI] 10.1371/journal.ppat.1008250.
[PMID] 31905230.
2020
RNase L promotes the formation of unique ribonucleoprotein granules distinct from stress granules.
The Journal of biological chemistry.
295(6):1426-1438
[DOI] 10.1074/jbc.RA119.011638.
[PMID] 31896577.
2019
RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs.
Molecular cell.
75(6):1203-1217.e5
[DOI] 10.1016/j.molcel.2019.07.029.
[PMID] 31494035.
2018
The Murine Polyomavirus MicroRNA Locus Is Required To Promote Viruria during the Acute Phase of Infection.
Journal of virology.
92(16)
[DOI] 10.1128/JVI.02131-17.
[PMID] 29875236.
2017
DUSP11 – An RNA phosphatase that regulates host and viral non-coding RNAs in mammalian cells.
RNA biology.
14(11):1457-1465
[DOI] 10.1080/15476286.2017.1306169.
[PMID] 28296624.
2017
Expression of short hairpin RNAs using the compact architecture of retroviral microRNA genes.
Nucleic acids research.
45(17)
[DOI] 10.1093/nar/gkx653.
[PMID] 28973449.
2016
DUSP11 activity on triphosphorylated transcripts promotes Argonaute association with noncanonical viral microRNAs and regulates steady-state levels of cellular noncoding RNAs.
Genes & development.
30(18):2076-2092
[PMID] 27798849.
2016
Neuroimaging overuse is more common in Medicare compared with the VA.
Neurology.
87(8):792-8
[DOI] 10.1212/WNL.0000000000002963.
[PMID] 27402889.
2015
Identification, validation, and characterization of noncanonical miRNAs.
Methods (San Diego, Calif.).
91:57-68
[DOI] 10.1016/j.ymeth.2015.07.013.
[PMID] 26210399.
2014
A central role for the primary microRNA stem in guiding the position and efficiency of Drosha processing of a viral pri-miRNA.
RNA (New York, N.Y.).
20(7):1068-77
[DOI] 10.1261/rna.044537.114.
[PMID] 24854622.
2014
Identification of tri-phosphatase activity in the biogenesis of retroviral microRNAs and RNAP III-generated shRNAs.
Nucleic acids research.
42(22):13949-62
[DOI] 10.1093/nar/gku1247.
[PMID] 25428356.
2014
Modeling test and treatment strategies for presymptomatic Alzheimer disease.
PloS one.
9(12)
[DOI] 10.1371/journal.pone.0114339.
[PMID] 25474698.
2014
Naturally arising strains of polyomaviruses with severely attenuated microRNA expression.
Journal of virology.
88(21):12683-93
[DOI] 10.1128/JVI.01933-14.
[PMID] 25142594.
2014
The effect of pre-Affordable Care Act (ACA) Medicaid eligibility expansion in New York State on access to specialty surgical care.
Medical care.
52(9):790-5
[DOI] 10.1097/MLR.0000000000000175.
[PMID] 24984209.
2013
Comprehensive mapping and analysis of Kaposi’s sarcoma-associated herpesvirus 3′ UTRs identify differential posttranscriptional control of gene expression in lytic versus latent infection.
Journal of virology.
87(23):12838-49
[DOI] 10.1128/JVI.02374-13.
[PMID] 24067953.
2013
Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells.
Cell host & microbe.
14(4):435-45
[DOI] 10.1016/j.chom.2013.09.002.
[PMID] 24075860.
2012
RNA virus microRNA that mimics a B-cell oncomiR.
Proceedings of the National Academy of Sciences of the United States of America.
109(8):3077-82
[DOI] 10.1073/pnas.1116107109.
[PMID] 22308400.
dsRNA-induced condensation of antiviral proteins promotes PKR activation
.
[DOI] 10.1101/2022.01.14.476399.
RNase L-mediated RNA decay alters 3’ end formation and splicing of host mRNAs
.
[DOI] 10.1101/2022.01.28.478180.
Grants
Sep 2023
ACTIVE
Understanding the OAS/RNase L pathway during pathogenic viral infections
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Education
Postdoctoral Fellow
2017-2022
·
University of Colorado Boulder
Ph.D.
2010-2016
·
University of Texas at Austin
B.S. Biochemistry
2006-2009
·
University of North Texas
Contact Details
Phones:
- Business:
- (561) 228-2784
Emails:
- Business:
- james.burke@ufl.edu
Administrative Spec III:
Addresses:
- Business Street:
-
Location C336
130 SCRIPPS WAY BLDG C
JUPITER FL 33458