Mauricio Martins Ph.D.
- Mailing Address:
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Location C221
130 SCRIPPS WAY BLDG, 2B2
JUPITER FL 33458
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Vaccine’s Young Investigator2016 · —
I am interested in developing practical immune interventions against globally relevant human pathogens. HIV is the current topic of my research. My group is using rhesus macaque models of HIV/AIDS to develop active and passive immunization strategies for preventing and treating HIV infection.
- 2024 Molecular Therapy
- 2019 PLOS Pathogens
- 2018 PLOS Pathogens
- 2017 PLOS Pathogens
Kendall Nettles Ph.D.
- Mailing Address:
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Location C238
130 SCRIPPS WAY BLDG 2C2
JUPITER FL 33458
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Best Thesis2003 · —
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Elaine Erhman Award for Research in Cancer Biology2002 · The Committee on Cancer Biology, The University of Chicago
- 2024 PNAS Nexus
- 2024 Journal of the American Chemical Society
- 2024 Journal of natural products
- 2024 Proceedings of the National Academy of Sciences of the United States of America
- 2024 bioRxiv : the preprint server for biology
- 2023 European journal of medicinal chemistry
- 2022 Science advances
- 2022 bioRxiv : the preprint server for biology
- 2022 Communications biology
- 2022 Communications Biology
- 2021 Proceedings of the National Academy of Sciences of the United States of America
- 2021 Nature chemical biology
- 2021 FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 2020 Breast cancer research and treatment
- 2019 Bioorganic & medicinal chemistry letters
- 2019 Nature communications
- 2019 mBio
- 2018 eLife
- 2018 Nature communications
- 2017 Nucleic acids research
- 2017 Cell chemical biology
- 2017 Bioorganic & medicinal chemistry letters
- 2017 Cancer research
- 2017 Molecular cell
- 2017 Nature chemical biology
- 2017 ACS chemical biology
- 2017 Journal of medicinal chemistry
- 2016 Molecular systems biology
- 2016 Oncotarget
- 2015 Nature communications
- 2015 Science translational medicine
- 2014 Journal of medicinal chemistry
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2014
Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network.eLife
- 2014 The EMBO journal
- 2013 Journal of medicinal chemistry
- 2013 Nature chemical biology
- 2013 Structure (London, England : 1993)
- 2012 The EMBO journal
- 2012 Structure (London, England : 1993)
- 2012 Journal of medicinal chemistry
- 2012 ChemMedChem
- 2012 Organic & biomolecular chemistry
- 2011 Biochemistry
- 2011 Chembiochem : a European journal of chemical biology
- 2010 Nature chemical biology
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2008
NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.Nature chemical biology
- 2008 Nature structural & molecular biology
- 2008 Molecular endocrinology (Baltimore, Md.)
- 2007 Journal of medicinal chemistry
- 2007 EMBO reports
- 2007 Structure (London, England : 1993)
- 2007 Chemistry & biology
- 2005 Annual review of physiology
- 2004 Molecular cell
- 2004 Ernst Schering Research Foundation workshop
- 2003 Molecular cell
- 2002 Nature structural biology
- 2000 Brain research
- 1997 Biological psychiatry
- 1996 Psychoneuroendocrinology
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2003
Ph.D. in Cancer BiologyThe University of Chicago
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1990
Bachelor's of Arts in PsychologyColgate University
Matthew Pipkin Ph.D.
- Mailing Address:
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Location C243
130 SCRIPPS WAY BLDG, 2C2
JUPITER FL 33458
The overall focus of the Pipkin lab is to elucidate how chromatin structure and transcription controls the gene expression programs that establish and maintain the differentiated states of T cells. The lab specifically studies how naïve CD8 T cells differentiate into effector and memory cytotoxic T lymphocytes (CTL). CTL are killer lymphocytes that hold outstanding promise for controlling viral infections and cancer therapeutically, as they can be employed in adoptive immunotherapy and are the target of successful vaccination. The Pipkin lab has developed novel approaches to map the fundamental repeating structures of chromatin (nucleosomes) at unprecedented resolution, novel reporter genes to track cells in vivo that induce expression of Prf1, an essential gene that is required for the anti-tumor killing activity of CTL, and the only systems to conduct genome-scale pooled RNAi screens in T cells, in vivo, during the course of actual viral infections. Using these tools and approaches, the Pipkin lab is clarifying how transcription factors govern the specific organization of nucleosomes that enforces CTL differentiation, identifying the chromatin regulatory factors that maintain the differentiated state epigenetically, and demonstrating how these processes mediate durable immunity.
- 2023 The Journal of Immunology
- 2023 Proceedings of the National Academy of Sciences of the United States of America
- 2023 bioRxiv : the preprint server for biology
- 2023 The Journal of Immunology
- 2022 Cold Spring Harbor perspectives in biology
- 2022 The Journal of Immunology
- 2021 Journal of virology
- 2021 Immunological reviews
- 2021 Journal of immunology (Baltimore, Md. : 1950)
- 2021 Nature
- 2021 The Journal of experimental medicine
- 2020 Cancer research
- 2020 The Journal of experimental medicine
- 2020 Nature immunology
- 2019 F1000Research
- 2018 Immunity
- 2018 Nature
- 2017 Nature
- 2017 Nature immunology
- 2017 Nature immunology
- 2015 Immunity
- 2015 Trends in immunology
- 2014 Immunity
- 2013 Proceedings of the National Academy of Sciences of the United States of America
- 2011 EMBO reports
- 2010 Immunological reviews
- 2010 Immunity
- 2009 The Journal of experimental medicine
- 2009 Journal of immunology (Baltimore, Md. : 1950)
- 2003 Journal of immunology (Baltimore, Md. : 1950)
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2005
Ph.D. in Microbiology and ImmunologyUniversity of Miami, School of Medicine
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1998
Bachelor's of Science in Microbiology and ImmunologyUniversity of Miami
Laura Solt Ph.D.
- Mailing Address:
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Location C227
130 SCRIPPS WAY BLDG 2C1
JUPITER FL 33458
Laura A. Solt, Ph.D., is an Associate Professor in the Department of Immunology and Microbiology at the Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology in Jupiter, Florida (formerly Scripps Florida). She received her B.A. from Boston College, her Ph.D. in Immunology from the University of Pennsylvania, and was a postdoctoral fellow at the Scripps Research Institute’s Jupiter, Florida campus (Scripps Florida). She started her independent laboratory at Scripps Florida in 2013 to gain further insight into the transcriptional regulation of nuclear receptors and their ligand(s) to better understand signaling pathways that govern Th17 cell homeostasis vs. pathogenicity and disease development. Her lab also works in close collaboration with medicinal chemists to design and develop small molecule ligands to nuclear receptors to further probe their functions and evaluate their therapeutic potential. Using these approaches, her lab has described roles for RORa and the REV-ERBs in Th17 cell development and developed synthetic ligands to these receptors to target Th17-mediated chronic inflammation and autoimmunity. Insight into the transcriptional regulation of nuclear receptors and their ligand(s) function is essential to comprehend the signaling pathways that govern Th17 cell homeostasis vs. pathogenicity as well as the rational design of therapeutics for specific disease indications.
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Ruth L. Kirschstein National Research Service Awards2010-2013 · National Institutes of Health
The underlying theme of the research performed in the Solt laboratory is to understand the biologically relevant roles of nuclear receptors, a superfamily of ligand regulated transcription factors, in the immune system. Our lab uses a combination of molecular biology, genetic, and chemical biology approaches coupled with mouse models of autoimmunity and chronic inflammation to study how different nuclear receptors’ expression, function, and activity affects disease. As ligand-regulated transcription factors, nuclear receptors are excellent therapeutic targets for the treatment of a variety of diseases. Therefore, we also work in collaboration with medicinal chemists to develop small molecule ligands to these receptors to further probe their function in vitro and in vivo. Each receptor is unique and can have ligand- and/or tissue-specific effects. Thus, we aim to gain a better understanding of nuclear receptor activity in tissue and disease-specific contexts to determine their therapeutic potential and for more rational drug design.
- Autoimmune Disease
- Cancer Immunotherapy
- Immunometabolism
- Mucosal immunology
- Neuroimmunology
- 2024 PNAS Nexus
- 2023 Journal of medicinal chemistry
- 2022 Immunometabolism
- 2022 SLAS discovery : advancing life sciences R & D
- 2022 Frontiers in immunology
- 2022 Immunometabolism
- 2021 Immunometabolism
- 2021 Science advances
- 2021 Nature communications
- 2021 Nature
- 2020 Biochemical and biophysical research communications
- 2020 Nature communications
- 2019 Proceedings of the National Academy of Sciences of the United States of America
- 2019 Nature
- 2019 Medicinal chemistry (Shariqah (United Arab Emirates))
- 2019 Science immunology
- 2018 Biochemical pharmacology
- 2018 Cell reports
- 2018 Bioorganic & medicinal chemistry letters
- 2018 PloS one
- 2018 PLoS biology
- 2016 PloS one
- 2016 PloS one
- 2016 European journal of immunology
- 2016 ACS chemical biology
- 2016 PloS one
- 2015 Diabetes management (London, England)
- 2015 Biochemical and biophysical research communications
- 2015 Endocrinology
- 2015 Cancer cell
- 2014 The Journal of biological chemistry
- 2014 Nature communications
- 2013 Nature medicine
- 2013 Pharmacological reviews
- 2013 ACS chemical biology
- 2012 Biochemistry
- 2012 PloS one
- 2012 Nature
- 2012 PloS one
- 2012 ACS chemical biology
- 2012 ACS chemical biology
- 2012 Trends in endocrinology and metabolism: TEM
- 2011 Future medicinal chemistry
- 2011 Nature
- 2011 ACS chemical biology
- 2011 The Journal of biological chemistry
- 2010 Molecular pharmacology
- 2010 The Journal of biological chemistry
- 2010 Endocrinology
- 2010 The Journal of biological chemistry
- 2010 Current opinion in lipidology
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2009-2013
Postdoctoral FellowThe Scripps Research Institute – Florida
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2008
Ph.D. in ImmunologyUniversity of Pennsylvania
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1998
Bachelor's of Science in PsychologyBoston College
Susana Valente Ph.D.
- Mailing Address:
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Location C329
130 SCRIPPS WAY BLDG 3C1
Jupiter FL 33458
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NIAID MERIT Award.2022 · Host factors regulating HIV latency and reactivation.
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Co-leader of HOPE (HIV Obstruction by Programmed Epigenetics) – Martin Delaney Collaboratory for HIV Cure (UM1)2021-current · NIH
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Founder2019-Current · Thimble Therapeutics
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Editorial Board2018-Current · Retrovirology
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Editorial Board2018-Current · Viruses
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Permanent member NIH- ADDT and HVCD study sections2014-2020 · NIH-NIAID
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Early Career Reviewer (ECR) program2012-2013 · NIH-NIAID
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Landenberger Foundation Award for early career investigators2010-2012 · Landenberger Foundation
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Research Scholar Development Award (K22)2009-2011 · NIAID
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Awarded2008 · NIAID Career Transition Award (K22)
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Awarded2007-2008 · Portuguese Ministry of Education Fellowship
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Awarded2005-2007 · American Foundation AIDS Research (amfAR) Fellowship
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Awarded1998-2002 · Portuguese Ministry of Education Scholarship
According to the latest statistics published by the UNAIDS/WHO in 2021, 38.4 million people were living with the Human Immunodeficiency Virus (HIV), and 40.1 million have died as a result of HIV. Although antiretroviral drugs have had a dramatically beneficial impact on HIV-infected individuals who have access to treatment, they have had a negligible impact on the global epidemic. Therapies for retroviral infections now used in clinical practice have limitations in that they often only shorten the duration of disease symptoms but fail to completely eradicate the virus with viral replication and disease recurring after discontinuation of the drug therapy. Additionally, the emergence of HIV variants with drug-resistance is an ongoing clinical problem. Clearly having a larger repertoire of therapeutic agents would be beneficial for combating the HIV epidemic.
Retroviruses, due to their limited genome size and content, require the assistance of multiple host cellular proteins at each step in their elaborate replication cycle. Host cells, in response, have evolved many mechanisms for inhibiting viral replication. We have taken a general approach to identify the molecular interactions occurring within a cell that are critical for viral replication, or genes that have evolved in mammalian cells to regulate viral replication. The discovery of cellular factors involved in retroviral replication and our increased knowledge of their mode of action may leverage novel antiviral approaches in clinical settings as one could block the modified use without affecting cell viability.
- 2024 Journal of virology
- 2024 Life science alliance
- 2024 Nature microbiology
- 2023 The Journal of biological chemistry
- 2023 Proceedings of the National Academy of Sciences of the United States of America
- 2023 Viruses
- 2023 Current opinion in HIV and AIDS
- 2022 SLAS discovery : advancing life sciences R & D
- 2022 Communications biology
- 2022 Viruses
- 2022 Methods in molecular biology (Clifton, N.J.)
- 2022 International journal of biological macromolecules
- 2022 Communications biology
- 2021 Journal of virology
- 2021 bioRxiv : the preprint server for biology
- 2021 The Journal of infectious diseases
- 2021 Nature Medicine
- 2021 mBio
- 2021 Cell reports
- 2020 International journal of pharmaceutics
- 2020 Viruses
- 2020 Colloids and surfaces. B, Biointerfaces
- 2020 Viruses
- 2019 FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 2019 Epigenetics & chromatin
- 2019 mBio
- 2019 Journal of virology
- 2019 mBio
- 2017 Current pharmaceutical design
- 2017 Methods in molecular biology (Clifton, N.J.)
- 2017 Cell reports
- 2016 Nature medicine
- 2016 Current HIV research
- 2016 Antimicrobial agents and chemotherapy
- 2016 Expert review of anti-infective therapy
- 2016 Angewandte Chemie (International ed. in English)
- 2015 mBio
- 2015 Frontiers in microbiology
- 2015 Current topics in microbiology and immunology
- 2015 Current HIV research
- 2014 Journal of visualized experiments : JoVE
- 2012 Biology
- 2012 Cell host & microbe
- 2009 Methods in molecular biology (Clifton, N.J.)
- 2009 Proceedings of the National Academy of Sciences of the United States of America
- 2009 Molecular cell
- 2007 The EMBO journal
- 2006 Molecular cell
- 2002 FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 2001 Journal of virology
- 1999 The Journal of general virology
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2009
Postodoctoral fellowColumbia University, NYC
-
2002
Ph.D. Microbiology-VirologyUniversity of Paris Diderot (Paris VII)
-
1998
Master's of Science in BiotechnologyDe Montfort University
-
1997
Master's of Science in Maîtrise BiochemistryUniversity of Paris Diderot (Paris VII)
-
1996
Bachelor's of Science in Applied Chemistry and BiotechnologyNew University of Lisbon