Immunology and Microbiology: Faculty Directory

Mauricio Martins

Mauricio Martins Ph.D.

Associate Professor
Phone: (561) 228-3051
Mailing Address:
Location C221
130 SCRIPPS WAY BLDG, 2B2
JUPITER FL 33458
Accomplishments:
  • Vaccine’s Young Investigator
    2016 ·
Research Summary:

I am interested in developing practical immune interventions against globally relevant human pathogens. HIV is the current topic of my research. My group is using rhesus macaque models of HIV/AIDS to develop active and passive immunization strategies for preventing and treating HIV infection.

Publications:
Kendall Nettles

Kendall Nettles Ph.D.

Associate Professor
Phone: (561) 228-3209
Mailing Address:
Location C238
130 SCRIPPS WAY BLDG 2C2
JUPITER FL 33458
Accomplishments:
  • Best Thesis
    2003 ·
  • Elaine Erhman Award for Research in Cancer Biology
    2002 · The Committee on Cancer Biology, The University of Chicago
Publications:
Education:
  • 2003
    Ph.D. in Cancer Biology
    The University of Chicago
  • 1990
    Bachelor's of Arts in Psychology
    Colgate University
Matthew Pipkin

Matthew Pipkin Ph.D.

Associate Professor
Phone: (561) 228-2182
Mailing Address:
Location C243
130 SCRIPPS WAY BLDG, 2C2
JUPITER FL 33458
Research Summary:

The overall focus of the Pipkin lab is to elucidate how chromatin structure and transcription controls the gene expression programs that establish and maintain the differentiated states of T cells. The lab specifically studies how naïve CD8 T cells differentiate into effector and memory cytotoxic T lymphocytes (CTL). CTL are killer lymphocytes that hold outstanding promise for controlling viral infections and cancer therapeutically, as they can be employed in adoptive immunotherapy and are the target of successful vaccination. The Pipkin lab has developed novel approaches to map the fundamental repeating structures of chromatin (nucleosomes) at unprecedented resolution, novel reporter genes to track cells in vivo that induce expression of Prf1, an essential gene that is required for the anti-tumor killing activity of CTL, and the only systems to conduct genome-scale pooled RNAi screens in T cells, in vivo, during the course of actual viral infections. Using these tools and approaches, the Pipkin lab is clarifying how transcription factors govern the specific organization of nucleosomes that enforces CTL differentiation, identifying the chromatin regulatory factors that maintain the differentiated state epigenetically, and demonstrating how these processes mediate durable immunity.

Publications:
Education:
  • 2005
    Ph.D. in Microbiology and Immunology
    University of Miami, School of Medicine
  • 1998
    Bachelor's of Science in Microbiology and Immunology
    University of Miami
Laura Solt

Laura Solt Ph.D.

Associate Professor; Associate Dean, Skaggs Graduate School Of Chemical And Biological Sciences
Phone: (561) 228-2295
Mailing Address:
Location C227
130 SCRIPPS WAY BLDG 2C1
JUPITER FL 33458

Laura A. Solt, Ph.D., is an Associate Professor in the Department of Immunology and Microbiology at the Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology in Jupiter, Florida (formerly Scripps Florida). She received her B.A. from Boston College, her Ph.D. in Immunology from the University of Pennsylvania, and was a postdoctoral fellow at the Scripps Research Institute’s Jupiter, Florida campus (Scripps Florida). She started her independent laboratory at Scripps Florida in 2013 to gain further insight into the transcriptional regulation of nuclear receptors and their ligand(s) to better understand signaling pathways that govern Th17 cell homeostasis vs. pathogenicity and disease development. Her lab also works in close collaboration with medicinal chemists to design and develop small molecule ligands to nuclear receptors to further probe their functions and evaluate their therapeutic potential. Using these approaches, her lab has described roles for RORa and the REV-ERBs in Th17 cell development and developed synthetic ligands to these receptors to target Th17-mediated chronic inflammation and autoimmunity. Insight into the transcriptional regulation of nuclear receptors and their ligand(s) function is essential to comprehend the signaling pathways that govern Th17 cell homeostasis vs. pathogenicity as well as the rational design of therapeutics for specific disease indications.

Accomplishments:
  • Ruth L. Kirschstein National Research Service Awards
    2010-2013 · National Institutes of Health
Research Summary:

The underlying theme of the research performed in the Solt laboratory is to understand the biologically relevant roles of nuclear receptors, a superfamily of ligand regulated transcription factors, in the immune system. Our lab uses a combination of molecular biology, genetic, and chemical biology approaches coupled with mouse models of autoimmunity and chronic inflammation to study how different nuclear receptors’ expression, function, and activity affects disease. As ligand-regulated transcription factors, nuclear receptors are excellent therapeutic targets for the treatment of a variety of diseases. Therefore, we also work in collaboration with medicinal chemists to develop small molecule ligands to these receptors to further probe their function in vitro and in vivo. Each receptor is unique and can have ligand- and/or tissue-specific effects. Thus, we aim to gain a better understanding of nuclear receptor activity in tissue and disease-specific contexts to determine their therapeutic potential and for more rational drug design.

Research Interests:
  • Autoimmune Disease
  • Cancer Immunotherapy
  • Immunometabolism
  • Mucosal immunology
  • Neuroimmunology
Publications:
Education:
  • 2009-2013
    Postdoctoral Fellow
    The Scripps Research Institute – Florida
  • 2008
    Ph.D. in Immunology
    University of Pennsylvania
  • 1998
    Bachelor's of Science in Psychology
    Boston College
Susana Valente

Susana Valente Ph.D.

Professor And Chair, Department Of Immunology And Microbiology
Phone: (561) 228-3454
Mailing Address:
Location C329
130 SCRIPPS WAY BLDG 3C1
Jupiter FL 33458
Accomplishments:
  • NIAID MERIT Award.
    2022 · Host factors regulating HIV latency and reactivation.
  • Co-leader of HOPE (HIV Obstruction by Programmed Epigenetics) – Martin Delaney Collaboratory for HIV Cure (UM1)
    2021-current · NIH
  • Founder
    2019-Current · Thimble Therapeutics
  • Editorial Board
    2018-Current · Retrovirology
  • Editorial Board
    2018-Current · Viruses
  • Permanent member NIH- ADDT and HVCD study sections
    2014-2020 · NIH-NIAID
  • Early Career Reviewer (ECR) program
    2012-2013 · NIH-NIAID
  • Landenberger Foundation Award for early career investigators
    2010-2012 · Landenberger Foundation
  • Research Scholar Development Award (K22)
    2009-2011 · NIAID
  • Awarded
    2008 · NIAID Career Transition Award (K22)
  • Awarded
    2007-2008 · Portuguese Ministry of Education Fellowship
  • Awarded
    2005-2007 · American Foundation AIDS Research (amfAR) Fellowship
  • Awarded
    1998-2002 · Portuguese Ministry of Education Scholarship
Research Summary:

According to the latest statistics published by the UNAIDS/WHO in 2021, 38.4 million people were living with the Human Immunodeficiency Virus (HIV), and 40.1 million have died as a result of HIV. Although antiretroviral drugs have had a dramatically beneficial impact on HIV-infected individuals who have access to treatment, they have had a negligible impact on the global epidemic. Therapies for retroviral infections now used in clinical practice have limitations in that they often only shorten the duration of disease symptoms but fail to completely eradicate the virus with viral replication and disease recurring after discontinuation of the drug therapy. Additionally, the emergence of HIV variants with drug-resistance is an ongoing clinical problem. Clearly having a larger repertoire of therapeutic agents would be beneficial for combating the HIV epidemic.

Retroviruses, due to their limited genome size and content, require the assistance of multiple host cellular proteins at each step in their elaborate replication cycle. Host cells, in response, have evolved many mechanisms for inhibiting viral replication. We have taken a general approach to identify the molecular interactions occurring within a cell that are critical for viral replication, or genes that have evolved in mammalian cells to regulate viral replication. The discovery of cellular factors involved in retroviral replication and our increased knowledge of their mode of action may leverage novel antiviral approaches in clinical settings as one could block the modified use without affecting cell viability.

Publications:
Education:
  • 2009
    Postodoctoral fellow
    Columbia University, NYC
  • 2002
    Ph.D. Microbiology-Virology
    University of Paris Diderot (Paris VII)
  • 1998
    Master's of Science in Biotechnology
    De Montfort University
  • 1997
    Master's of Science in Maîtrise Biochemistry
    University of Paris Diderot (Paris VII)
  • 1996
    Bachelor's of Science in Applied Chemistry and Biotechnology
    New University of Lisbon