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Gene Therapy Switch Allows Control of Gene Therapy Doses

JUPITER, FLA – Scientists at UF Scripps Biomedical Research have developed a special molecular switch that could be embedded into gene therapies to allow doctors to control dosing. The feat, reported in the scientific journal Nature Biotechnology, offers gene therapy designers what may be the first viable…

PTSD Study Identifies Potential Target for Memory Disruption

Professor Courtney Miller, PhD, of the departments of Neuroscience and Molecular Medicine. JUPITER, FL — Fight or flight, panic, trembling: Our brains are wired to ensure we respond instantly to fear. While that fear response may save our lives in the dangerous moment, at times people stay on high…

Discovery of Bacteria’s Protein Quality Control Agent Offers Insight Into Origins of Life

JUPITER, FL —  Our cells’ process for transforming genes into useful proteins works much like an automobile factory’s assembly line; there are schematics, parts, workers, motors, quality control systems and even recycling crews. If the cell’s recycling process falters, abnormal protein fragments accumulate, potentially causing the cell’s death. In nerve…

Opioid Users Could Benefit From Meth-Relapse Prevention Strategy, Study Finds

Professor Courtney Miller is developing a compound designed to directly target neurons involved in methamphetamine cravings. Photo by Scott Wiseman. JUPITER, FL – New research raises the possibility that a wider group of people in recovery from substance use disorders may benefit from a relapse-prevention compound designed by UF Scripps…

Two-Pronged Antibodies Draw Immune Killers Directly to Cancer Cells

The structure of the ROR1-binding arm of the bi-specific antibody in complex with ROR1 was determined by X-ray crystallography. Our immune system’s arsenal of defenses usually protects us from cancer. But sometimes, cancer cells overwhelm or evade this elaborate defense system. In a study in PNAS, Immunology and Microbiology…

New Potential Painkillers Reduce Overdose Risk

JUPITER, FL – Scientists at UF Scripps Biomedical Research have developed new opioid pain relievers that reduce pain on par with morphine but do not slow or stop breathing—the cause of opiate overdose. The research, published today in the journal Cell, describes a method for making safer opioid painkillers. According…