Two scientists at UF Scripps have been recognized with "Invention of the Year" awards from UF Innovate. Read about their inventions.
The most effective pain relievers lose power over time. Scientists discover a gene that controls cholesterol in the cell membrane plays a key role.
Nanotube tunnels that act like roadways capable of transporting cargo between cells can transmit a toxic protein linked to Huntington’s disease, a new study finds.
“The compound SR-17018 is the first biased agonist of the mu opioid receptor that does not lead to tolerance with chronic use,” says Stahl, a senior staff scientist in the Bohn lab. “This is a desirable feature for potential use in the context of chronic, severe pain.”
Disney designed the ALS compound by applying nearly 15 years of research finding druggable structures on RNA.
Rumbaugh lab found that the gene Syngap1 enables normally quiet neurons to spring into activity during sensory challenges, while other neurons are quieted.
If KIF5C is knocked out, the team found, the neurons’ ability to branch out dendrites and form input-receiving spines suffers.
When the brain’s synapses are activated, they set off a signaling cascade that results in the expression of long noncoding RNA called “ADEPTR.” The RNA is quickly transported along dendrites to synapses, where it acts on proteins involved in remodeling. (Image courtesy of Jenna Wingfield and Yibo Zhao of the…
Mutations to Dyrk1a gene lead to brain undergrowth with features of autism and intellectual disability. An existing drug rescues the condition in newborn mice, Scripps Florida scientists find.
Subramaniam shows that the mutated huntingtin protein slows brain cells’ protein-building machines, called ribosomes.