A team led by chemistry professor Ben Shen, Ph.D., discovered a potent anti-cancer compound within the institute's natural products collection. It has been connected to a precise cancer-seeking antibody with an innovative linker molecule.
Enediynes can bind and break DNA, leading to cell death. As a result, they have enormous potential as antibiotics and cancer drugs. A new study reveals how nature assembles them.
The natural products collection at Scripps Florida contains hundreds of thousands of organisms available for study. Advance provides new tools for synthetic chemists and biologists looking to probe and modify sulfur-based biochemistry JUPITER, FL—A group of highly reactive compounds called persulfides have provoked great curiosity among biochemists,…
By distorting estrogen receptor shape in two different ways, compounds offer a two-for-one punch to estrogen-sensitive cancer cells. Kendall Nettles, PhD, (center) meets with two students in his lab, Jacqline Njeri (left) and Charles Min (right). Nettles and colleagues designed drug-like molecules that appear to fight estrogen-sensitive breast cancer in…
The scientists have devised a way to lock HIV in its dormant stage. Now they want to throw away the key.
Mutations to Dyrk1a gene lead to brain undergrowth with features of autism and intellectual disability. An existing drug rescues the condition in newborn mice, Scripps Florida scientists find.
Scientists devise process for making precision anti-inflammatory medicines with fewer side-effects at UF Scripps Biomedical Research in Jupiter, Florida.
The three enzymes used, to construct the terpines were identified only last year, from the microbial strain collection at UF Scripps' Natural Products Discovery Center.
Altering the activity of the PPARg receptor could limit the side-effects of a useful group of diabetes drugs, TZDs.
