Alicia Angelbello, Ph.D., a student of the Skaggs Graduate School, studied with UF Scripps Chemistry Department Chair Matthew Disney, Ph.D. She has been awarded the American Chemical Society’s Nobel Signature Award. UF Scripps Chemist Matthew Disney and Skaggs Graduate School student Alicia Angelbello devised a way to potentially treat a…
Like a carpenter switching drill bits depending on the job at hand, scientists at Scripps Research in Florida have changed an investigational medicine’s activity by swapping in different molecular tools, in the process, showing a potential new way to address multiple incurable diseases.
Disney lab at UF Scripps developed a compound that disables the replication engine of COVID-19 by disabling its viral "clutch."
The three enzymes used, to construct the terpines were identified only last year, from the microbial strain collection at UF Scripps' Natural Products Discovery Center.
"This compound can stop its messenger RNA from being recognized by a ribosome," professor Disney said. "We believe this unique mechanism is broadly applicable."